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AB152802

Recombinant Human WASP/Wiskott-Aldrich syndrome protein (GST tag N-Terminus)

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Recombinant Human WASP/Wiskott-Aldrich syndrome protein (GST tag N-Terminus) is a Human Fragment protein, in the 57 to 170 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

IMD2, WAS, Actin nucleation-promoting factor WAS, Wiskott-Aldrich syndrome protein, WASp

1 이미지
SDS-PAGE - Recombinant Human WASP/Wiskott-Aldrich syndrome protein (GST tag N-Terminus) (AB152802)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human WASP/Wiskott-Aldrich syndrome protein (GST tag N-Terminus) (AB152802)

12.5% SDS-PAGE analysis of ab152802 stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB133411

Low Fluorescence Western Membrane (PVDF)

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Proteins & Peptides

AB132277

Recombinant Human N WASP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human N WASP protein (GST tag N-Terminus) (AB132277)

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Primary Antibodies

AB75830

Anti-WASP/Wiskott-Aldrich syndrome protein antibody [EP2541Y]

RabMAb|Recombinant|Trial Size

Flow Cytometry (Intracellular) - Anti-WASP/Wiskott-Aldrich syndrome protein antibody [EP2541Y] (AB75830)

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Proteins & Peptides

AB94517

Recombinant human CD45 protein (His tag N-Terminus)

Functional Studies - Recombinant human CD45 protein (AB94517)

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  • 0
Proteins & Peptides

AB60848

Recombinant human PKC zeta protein (GST tag N-Terminus)

Functional Studies - Recombinant human PKC zeta protein (AB60848)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as WASP.
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서열 정보

[{"linker":null,"sequence":"LPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEER","proteinLength":"Fragment","predictedMolecularWeight":"38.28 kDa","actualMolecularWeight":null,"aminoAcidEnd":170,"aminoAcidStart":57,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P42768","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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일반 정보

기능

Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed : 12235133, PubMed : 12769847, PubMed : 16275905). Important for efficient actin polymerization (PubMed : 12235133, PubMed : 16275905, PubMed : 8625410). Possible regulator of lymphocyte and platelet function (PubMed : 9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed : 18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed : 20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed : 29925947).

Post-translational modifications

Phosphorylated at Tyr-291 by FYN and HCK, inducing WAS effector activity after TCR engagement. Phosphorylation at Tyr-291 enhances WAS activity in promoting actin polymerization and filopodia formation.

Subcellular localisation

Cytoskeleton

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제품 프로토콜

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타겟 정보

Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed : 12235133, PubMed : 12769847, PubMed : 16275905). Important for efficient actin polymerization (PubMed : 12235133, PubMed : 16275905, PubMed : 8625410). Possible regulator of lymphocyte and platelet function (PubMed : 9405671). Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed : 18650809). In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed : 20574068). Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed : 29925947).
See full target information WAS
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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