Recombinant Influenza B Virus Nucleoprotein (His tag)
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Recombinant Influenza B Virus Nucleoprotein (His tag) is a Influenza B virus (B/Lee/1940) Full Length protein, in the 1 to 560 aa range, expressed in Yeast, with >90%, suitable for SDS-PAGE.
대체 명칭 보기
Nucleoprotein, Nucleocapsid protein, Protein N, NP, Influenza B Virus NP, NP, Nucleocapsid protein, Nucleoprotein, Protein N
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Influenza B Virus Nucleoprotein (His tag) (AB238364)
ab238364 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
보완 제품
Reagents, Controls & Accessories
AB116027
Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)
- 5
- 2
Primary Antibodies
AB313343
Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17]
20ul selling size|RabMAb|Recombinant
![Immunocytochemistry/ Immunofluorescence - Anti-Influenza A Virus Nucleoprotein antibody [EPR28253-17] (AB313343)](https://content.abcam.com/products/images/influenza-a-virus-nucleoprotein-antibody-epr28253-17-ab313343--immunocytochemistry-immunofluorescence-img417512.jpg)
- 5
- 1
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
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적절한 단기 보관 조건
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보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The ribonucleoprotein complex formation involves nucleoproteins assembling with the viral RNA and polymerase subunits securing the genome for replication and transcription. NP interacts with both the polymerase basic 2 (PB2) and polymerase acidic (PA) proteins forming a vital part of the complex. This interaction allows the viral RNA to maintain its structure and function effectively during the virus infection cycle aiding both Influenza A and B viruses.
Pathways
NP participates in the viral replication pathway supporting the influenza virus propagation in infected cells. It associates closely with viral RNA polymerases and is integral to the transcription and replication of the viral RNA genome. Other key proteins involved in these pathways include the polymerase basic 1 (PB1) protein essential for synthesizing viral mRNA and the matrix protein (M1) which aids in vRNA encapsidation and budding.
일반 정보
기능
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
서열 유사성
Belongs to the influenza viruses nucleoprotein family.
Post-translational modifications
Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.
Subcellular localisation
Host nucleus
타겟 정보
Additional targets
Product promise
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