Recombinant Mouse AMH protein is a Mouse Fragment protein, in the 450 to 552 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
대체 명칭 보기
Anti-Muellerian hormone, AMH, Muellerian-inhibiting factor, Muellerian-inhibiting substance, MIS, Amh
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235617 indicates that this peptide derived from E.coli-expressed Mus musculus (Mouse) Amh.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Mouse AMH protein (AB235617)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of ab235617 indicates that this peptide derived from E.coli-expressed Mus musculus (Mouse) Amh.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse AMH protein (AB235617)
ab235617 analyzed by (Tris-Glycine gel) discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
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보관 정보
일반 정보
기능
The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (PubMed : 11606457, PubMed : 11861535, PubMed : 1782869, PubMed : 9435237). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (PubMed : 1782869, PubMed : 9435237). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed : 11606457, PubMed : 11861535). Also plays a role in Leydig cell differentiation and function (PubMed : 1782869, PubMed : 9435237).. Plays an important role in several reproductive functions, including Muellerian duct regression during male fetal sexua,l differentiation and in the adult plays a role in Leydig cell differentiation and function (PubMed : 1782869, PubMed : 9435237). In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (PubMed : 11606457, PubMed : 11861535). Binds to its sole type II receptor, AMHR2 that recruits type I receptors ACVR1 and BMPR1A which subsequently activates the Smad pathway (By similarity).
서열 유사성
Belongs to the TGF-beta family.
Post-translational modifications
The preproprotein is proteolytically processed to generate the AMH prodomain and the anti-Muellerian hormone (By similarity). Both homodimerize covalently, and homodimers associate to form a non-covalent heterotetrameric complex (By similarity).
타겟 정보
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