Recombinant Mouse Ccr1 Protein (His Tag) is a Mouse Full Length protein, in the 1 to 355 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
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CD191, Cmkbr1, Ccr1, C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, Macrophage inflammatory protein 1-alpha receptor, RANTES-R, MIP-1alpha-R
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Mouse Ccr1 Protein (His Tag) (AB314614)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. It is speculated that the protein forms a dimeric structure. Observed band size : Monomer：44 kDa Dimer：90 kDa
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제형
Purification 테크닉
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적절한 단기 보관 기간
적절한 단기 보관 조건
적절한 장기 보관 조건
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCR1 involves itself in processes such as leukocyte migration and inflammatory response. The receptor interacts with specific chemokines of the C-C motif like CCL3 and CCL5. CCR1 does not operate within a higher-order protein complex but binds directly to these chemokines leading to signal transduction that alters cell functions. By modulating immune cell behaviors CCR1 helps orchestrate immune surveillance and inflammation.
Pathways
CCR1 plays a significant part in immune-related pathways such as chemokine signaling and the inflammatory response. It transduces signals via G-protein coupled receptor pathways influencing downstream signaling molecules including PI3K and AKT. Apart from its direct chemokine interactions CCR1 regulates functions in concert with proteins like CCR5 another chemokine receptor coordinating the migration and activation of immune cells across tissues.
일반 정보
기능
Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed : 9166425). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (By similarity). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (PubMed : 15831559). Also mediates monocyte migration upon CXCL4 binding (By similarity). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (PubMed : 31898284).
서열 유사성
Belongs to the G-protein coupled receptor 1 family.
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