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AB214615

Recombinant mouse CD200 / OX2 protein

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Recombinant mouse CD200 / OX2 protein is a Mouse Fragment protein, in the 31 to 236 aa range, expressed in CHO cells, with >98%, < 0.06 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

주요 정보

Purity

>98% SDS-PAGE

Endotoxin 레벨

< 0.06 EU/µg

발현 시스템

CHO cells

Tags

Mutant mouse IgG2a Fc tag N-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Shows the biological function of the CD200 / OX2 moiety and exerts a prolonged circulating halflife caused by the modified Fc domain.

Accession

O54901-1

Animal free

No

Carrier free

Yes

Species

Mouse

Reconstitution

Reconstitute at 100 µg/mL in sterile PBS. Working aliquots are stable for up to 3 months when stored at -20°C.

보관 버퍼

Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB254193

Anti-CD200 / OX2 antibody [EPR22412-229]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-CD200 / OX2 antibody [EPR22412-229] (AB254193)

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Assay Kits

AB267806

Human CD200 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CD200 ELISA Kit (AB267806)

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Primary Antibodies

AB32142

Anti-p38 beta/MAPK11 + p38 alpha/MAPK14 antibody [Y122]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p38 beta/MAPK11 + p38 alpha/MAPK14 antibody [Y122] (AB32142)

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Proteins & Peptides

AB125643

Recombinant human p38 delta/MAPK13 protein (GST tag N-Terminus)

Functional Studies - Recombinant human p38 delta/MAPK13 protein (AB125643)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"QVEVVTQDERKALHTTASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQPAYKDRINVTELGLWNSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQPIVHLHYNYFEDHLNITCSATARPAPAISWKGTGTGIENSTESHFHSNGTTSVTSILRVKDPKTQVGKEVICQVLYLGNVIDYKQSLDKGFWFS","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":236,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"CHO cells","accessionNumber":"O54901","tags":[{"tag":"Mutant mouse IgG2a Fc","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle|Stable for 12 months at -20°C
True
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.
Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.
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일반 정보

기능

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).

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제품 프로토콜

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타겟 정보

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).
See full target information Cd200

대체 명칭 보기

CD200, Mox2, Cd200, OX-2 membrane glycoprotein, MRC OX-2 antigen
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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