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AB315426

Recombinant Mouse FGF-15 protein

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Recombinant Mouse FGF-15 protein is a Mouse Full Length protein, in the 26 to 218 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

Fibroblast growth factor 15, FGF-15, Fgf15

1 이미지
SDS-PAGE - Recombinant Mouse FGF-15 protein (AB315426)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse FGF-15 protein (AB315426)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel on purified ab315426 expressed in E.coli.

주요 정보

Purity

>90% SDS-PAGE

발현 시스템

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Mouse

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

보관 버퍼

pH: 8 Constituents: 6% Trehalose, 0.158% Tris HCl, 0.029% Ethylenediaminetetraacetic acid, disodium, dihydrate

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

  • 0
  • 0
Proteins & Peptides

AB283418

Recombinant human FGF19 protein (Active)

Premium Bioactive

Mass Spectrometry - Recombinant human FGF19 protein (Active) (AB283418)

  • 0
  • 0
Primary Antibodies

AB319994

Anti-FGF-15 antibody [EPR29018-80]

20ul selling size|Recombinant|RabMAb

Western blot - Anti-FGF-15 antibody [EPR29018-80] (AB319994)

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  • 0
Primary Antibodies

AB129089

Anti-FXR1 antibody [EPR7932]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-FXR1 antibody [EPR7932] (AB129089)

  • 5
  • 1
Primary Antibodies

AB228949

Anti-Bile Acid Receptor/FXR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bile Acid Receptor/FXR antibody (AB228949)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL
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서열 정보

[{"linker":null,"sequence":"RPLAQQSQSVSDEDPLFLYGWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDVSSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIQAKPREQLQDQKPSNFIPVFHRSFFETGDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK","proteinLength":"Full Length","predictedMolecularWeight":"38.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":218,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O35622","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
Purification 테크닉
Ion exchange chromatography
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C|-80°C
분주 정보
Add glycerol to a final volume of 50% for extra stability and aliquot
보관 정보
The product can be stored for up to 12 months
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FGF-15 also known as fibroblast growth factor 15 is a protein with a significant role in various physiological processes. This protein belongs to the fibroblast growth factor (FGF) family and has a molecular mass of approximately 25 kDa. FGF-15 is predominantly expressed in the intestines particularly in the ileum. Its main mechanical function involves the modulation of bile acid synthesis which occurs through its actions on specific receptor targets.
Biological function summary

FGF-15 plays a critical role in liver function and metabolism. It acts as a regulatory factor in bile acid homeostasis and glucose metabolism ensuring the balance and maintenance within the body. FGF-15 does not primarily function as part of a protein complex but it exerts its influence by binding to the fibroblast growth factor receptor 4 (FGFR4) associated with the β-Klotho co-receptor eliciting a signaling cascade important for maintaining metabolic homeostasis.

Pathways

FGF-15 engages in the enterohepatic circulation of bile acids and has a pivotal role in the suppression of bile acid synthesis. One of the key pathways involves fibroblast growth factor receptor signaling pathway. In this capacity FGF-15 works in conjunction with proteins such as FGFR4 and β-Klotho forming a signaling axis that influences the expression of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) an important enzyme in bile acid biosynthesis.

FGF-15 is closely associated with metabolic conditions particularly liver diseases such as non-alcoholic fatty liver disease (NAFLD). Elevated levels of protein expression or dysregulation of its pathway may contribute to the development or progression of such disorders. Additionally abnormalities in the FGF-15 signaling can also impact glucose homeostasis linking it to diabetes. In these contexts FGF-15 works closely with FGFR4 and β-Klotho both important in the therapeutic targeting of these metabolic diseases.
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일반 정보

기능

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.

서열 유사성

Belongs to the heparin-binding growth factors family.

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제품 프로토콜

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타겟 정보

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
See full target information Fgf15
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Product promise

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