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AB289775

Recombinant Mouse GPCR GPR146 protein

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Recombinant Mouse GPCR GPR146 protein is a Mouse Full Length protein, in the 1 to 333 aa range, expressed in Cell free, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

G-protein coupled receptor 146, Gpr146

1 이미지
SDS-PAGE - Recombinant Mouse GPCR GPR146 protein (AB289775)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse GPCR GPR146 protein (AB289775)

SDS-PAGE analysis of ab289775

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Cell free

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Mouse

보관 버퍼

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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보완 제품

Primary Antibodies

AB134811

Anti-GPCR GPR34 antibody

Immunocytochemistry/ Immunofluorescence - Anti-GPCR GPR34 antibody (AB134811)

  • 0
  • 0
Primary Antibodies

AB283654

Anti-CD68 antibody [EPR23917-164]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size|Advanced Validation

Flow Cytometry - Anti-CD68 antibody [EPR23917-164] (AB283654)

  • 5
  • 1
Primary Antibodies

AB179466

Anti-PML Protein antibody [EPR16792]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PML Protein antibody [EPR16792] (AB179466)

  • 5
  • 5
Primary Antibodies

AB199177

Anti-GPR182 antibody - Membrane Vesicle Marker

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPR182 antibody - Membrane Vesicle Marker (AB199177)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLLYLGAGVPVSLGYNALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHVTLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFSSLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTPLDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPGKLRRLMKKMHCGRRHCSPDPSGIQQVMAQA","proteinLength":"Full Length","predictedMolecularWeight":"39.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":333,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Cell free","accessionNumber":"Q99LE2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

G protein-coupled receptor 146 commonly known as GPCR GPR146 is a member of the extensive GPCR family involved in cell signaling. It weighs approximately 42 kDa. GPR146 is located on the cell membrane mainly expressed in the brain and heart tissues. This protein like other GPCRs works by activating intracellular signal transduction pathways in response to extracellular signals.
Biological function summary

GPCR GPR146 binds with specific ligands initiating a signaling cascade that affects cellular responses. While no solid evidence indicates that GPR146 forms part of a complex it seems to interact with G proteins. This interaction stimulates secondary messenger pathways which can modulate various physiological processes.

Pathways

GPR146 is implicated in the G protein signaling pathway influencing processes like neurotransmission and cardiovascular regulation. It maintains connections with other proteins in these pathways such as G proteins and adenylate cyclases which are important for propagating signal transduction events within the cell ultimately influencing cellular responses.

GPCR GPR146 has been linked to atherosclerosis and cardiovascular diseases. Alterations in GPCR GPR146 could disrupt normal signal transduction contributing to these conditions. It shows relations to other proteins involved in these disorders such as LDL receptors which highlights its significance in lipid metabolism and cardiovascular health.
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일반 정보

기능

GPCR receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).

서열 유사성

Belongs to the G-protein coupled receptor 1 family.

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제품 프로토콜

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타겟 정보

GPCR receptor required for the regulation of plasma cholesterol levels (PubMed : 31778654, PubMed : 38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed : 38503280).
See full target information Gpr146
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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