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AB233634

Recombinant mouse IGF2 protein (Animal Free)

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Recombinant mouse IGF2 protein (Animal Free) is a Mouse Full Length protein, in the 25 to 91 aa range, expressed in Escherichia coli, with >95%, <1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

대체 명칭 보기

Igf-2, Igf2, Insulin-like growth factor 2, Insulin-like growth factor II, Multiplication-stimulating polypeptide, IGF-II

2 이미지
Functional Studies - Recombinant mouse IGF2 protein (Animal Free) (AB233634)
  • FuncS

Supplier Data

Functional Studies - Recombinant mouse IGF2 protein (Animal Free) (AB233634)

ab233634 induced proliferation of FDC-P1 cells.

SDS-PAGE - Recombinant mouse IGF2 protein (Animal Free) (AB233634)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant mouse IGF2 protein (Animal Free) (AB233634)

1 μg ab233634 analyzed on a 4-20% Tris-Glycine gel, stained with Coomassie Blue.

Lane 1 : Non-reducing conditions.

Lane 2 : Reducing conditions.

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

<1 EU/µg

발현 시스템

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

FDC-P1 cell proliferation. ED50 ≤ 50 ng/ml (≥ 2.0 x 104 units/mg).

Accession

Animal free

Yes

Carrier free

No

Species

Mouse

Reconstitution

Reconstitute at 0.1 mg/mL in water

보관 버퍼

Constituents: 0.1% Trifluoroacetic acid

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116028

Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa) (AB116028)

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  • 3
Proteins & Peptides

AB270062

Recombinant human IGF1 protein (Active)

Premium Bioactive

Functional Studies - Recombinant human IGF1 protein (Active) (AB270062)

  • 5
  • 1
Proteins & Peptides

AB280348

Recombinant mouse IGF1 protein (Active)

Premium Bioactive

Functional Studies - Recombinant mouse IGF1 protein (Active) (AB280348)

  • 0
  • 0
Primary Antibodies

AB182408

Anti-IGF1 Receptor antibody [EPR19322]

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry - Anti-IGF1 Receptor antibody [EPR19322] (AB182408)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"AYGPGETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSE","proteinLength":"Full Length","predictedMolecularWeight":"7.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":91,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P09535","tags":[]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
True
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일반 정보

기능

The insulin-like growth factors possess growth-promoting activity (PubMed : 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed : 12087403, PubMed : 2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed : 16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed : 32557799).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

서열 유사성

Belongs to the insulin family.

Post-translational modifications

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.

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제품 프로토콜

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타겟 정보

The insulin-like growth factors possess growth-promoting activity (PubMed : 29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed : 12087403, PubMed : 2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed : 16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed : 32557799).. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
See full target information Igf2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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