Recombinant Mouse IL-18 protein (His tag)

일반 정보

기능

Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed : 26638072, PubMed : 26638073). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis : its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed : 30392956).

서열 유사성

Belongs to the IL-1 family.

Post-translational modifications

The pro-IL-18 precursor is processed by CASP1 to yield its mature, active form (PubMed:37993712, PubMed:37993714). The pro-IL-18 precursor is however not processed by Casp4/Casp11 in rodents (PubMed:37993712, PubMed:37993714). The pro-IL-18 precursor features autoinhibitory interactions between the propeptide and the post-cleavage-site region, preventing recognition by the IL18R1 receptor (By similarity). Processing by CASP1 induces conformational changes to generate critical receptor-binding sites (By similarity). The mature form is then secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (By similarity). In contrast, cleavage by CASP3 inactivates IL18 (By similarity).