Recombinant Mouse NT-proBNP Protein Standard

일반 정보

기능

Brain natriuretic peptide 45. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (PubMed : 8182124). May also function as a paracrine antifibrotic factor in the heart (PubMed : 10737768). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses (PubMed : 8182124). Likely involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, kaluresis and chloruresis (By similarity).

서열 유사성

Belongs to the natriuretic peptide family.

Post-translational modifications

The precursor molecule is proteolytically cleaved by the endoprotease Furin to produce brain natriuretic peptide 45 (By similarity). May undergo further proteolytic cleavage by various proteases such as DPP4, MME and possibly FAP, to give rise to a variety of shorter peptides (By similarity). May be cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (By similarity). May be degraded by IDE (By similarity). During IDE degradation, the resulting products initially increase the activation of NPR1 and can also stimulate NPR2 to produce cGMP before the fragments are completely degraded and inactivated by IDE (in vitro) (By similarity).