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AB276927

Recombinant Mouse ST6GALNAC2 protein

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Recombinant Mouse ST6GALNAC2 protein is a Mouse Fragment protein, in the 28 to 373 aa range, expressed in HEK 293 cells, with >98%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

Siat7, Siat7b, St6galnac2, ST6GalNAc II, Sialyltransferase 7B, ST6GalNAcII, SIAT7-B

1 이미지
SDS-PAGE - Recombinant Mouse ST6GALNAC2 protein (AB276927)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Mouse ST6GALNAC2 protein (AB276927)

SDS-PAGE analysis of ab276927

주요 정보

Purity

>98% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Mouse

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Primary Antibodies

AB131553

Anti-CFTR antibody

Immunocytochemistry/ Immunofluorescence - Anti-CFTR antibody (AB131553)

  • 5
  • 1
Primary Antibodies

AB255610

Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Stanniocalcin 2/STC-2 antibody [EPR22866-10] (AB255610)

  • 5
  • 2
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

  • 0
  • 0
Primary Antibodies

AB214488

Anti-TROP2 antibody [EPR20043]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Western blot - Anti-TROP2 antibody [EPR20043] (AB214488)

  • 5
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"SAGQQSPETQVPARNMAYPRAFFDPKPPNSENRKSRLCQHSLSLAIQKDRRFRSLFDLSTPVLLWEGLFTQELWNNLSQHKVPYGWQGLSHEVIASTLRLLKSPESGELFGAPRKLPLSCIRCAVVGNGGILNGSRQGQKIDAHDYVFRLNGAITEGFERDVGTKTSFYGFTVNTMKNSLISYAKLGFTSVPQGQNLRYIFIPSSIRDYLMLRSAILGVPVPEGPDKGDRPHTYFGPETSASKFKLLHPDFISYLTERFLKSKLINTRFGDMYMPSTGALMLLTALHTCDQVSAYGFITNNYQKYSDHYFEREKKPLIFYANHDLSLEASLWRDLHNAGILWLYQR","proteinLength":"Fragment","predictedMolecularWeight":"40.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":28,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P70277","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ST6GALNAC2 also known as GalNAc α-26-sialyltransferase 2 is an enzyme involved in the sialylation process. Its molecular mass is approximately 56 kDa. The enzyme is expressed prominently in human tissues like the colon small intestine and spleen. ST6GALNAC2 catalyzes the transfer of sialic acid from CMP-NeuAc to GalNAc residues of glycoproteins and glycolipids playing a role in modifying their structures.
Biological function summary

The enzyme has a significant role in the biosynthesis of sialylated structures influencing cell-cell interactions signaling and immune modulation. ST6GALNAC2 is part of the glycosyltransferase family and it acts without forming larger complexes. Its activity affects the surface glycosylation pattern of cells influencing properties like cell adhesion and signaling pathways that are critical for cellular communication.

Pathways

Sialylation influences cellular interactions and immune responses and ST6GALNAC2's addition of sialic acid units impacts these processes. It participates in the glycosphingolipid biosynthesis pathway and influences the sialylation branch of the Nglycosylation pathway. ST6GALNAC2's activities interplay with other sialyltransferases in regulating the sialylation state of glycoproteins affecting interactions with receptors such as selectins and integrins which are important in mediating cellular adhesion and trafficking.

Altered ST6GALNAC2 activity links to colorectal cancer and inflammatory bowel diseases. In colorectal cancer modifications in glycosylation patterns influenced by ST6GALNAC2 and related enzymes like ST6GALNAC1 correlate with tumor progression and metastasis. In inflammatory bowel diseases the enzyme contributes to changes in the mucosal barrier affecting immune responses and tissue integrity. Understanding ST6GALNAC2's role offers insights into therapeutic targets in these diseases.
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일반 정보

기능

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 8662927). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 8662927).

서열 유사성

Belongs to the glycosyltransferase 29 family.

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제품 프로토콜

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타겟 정보

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed : 8662927). Shows a preference for N-acetylgalactosamine (GalNAc) residues already modified by the addition of galactose or galactose followed by sialic acid in alpha-2,3 linkage (PubMed : 8662927).
See full target information St6galnac2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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