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AB208465

Recombinant Mouse WIF1 protein (His tag C-Terminus)

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Recombinant Mouse WIF1 protein (His tag C-Terminus) is a Mouse Full Length protein, in the 29 to 379 aa range, expressed in Insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

Wnt inhibitory factor 1, WIF-1, Wif1

1 이미지
SDS-PAGE - Recombinant Mouse WIF1 protein (His tag C-Terminus) (AB208465)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Mouse WIF1 protein (His tag C-Terminus) (AB208465)

15% SDS-PAGE analysis of ab208465 (3 μg)

주요 정보

Purity

>90% SDS-PAGE

Affinity purified

Endotoxin 레벨

< 1 EU/µg

발현 시스템

Insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Mouse

보관 버퍼

pH: 5.5 Constituents: 30% Glycerol (glycerin, glycerine), 0.39% MES, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.02% PMSF

storage-buffer

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보완 제품

Proteins & Peptides

AB289780

Recombinant Human Wnt7b protein

SDS-PAGE - Recombinant Human Wnt7b protein (AB289780)

  • 0
  • 0
Primary Antibodies

AB155101

Anti-WIF1 antibody [EPR9385]

RabMAb|Recombinant

Immunoprecipitation - Anti-WIF1 antibody [EPR9385] (AB155101)

  • 5
  • 2
Proteins & Peptides

AB49001

Recombinant Human VAMP2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human VAMP2 protein (His tag N-Terminus) (AB49001)

  • 0
  • 0
Proteins & Peptides

AB116171

Recombinant human Wnt7a protein

Bioactive

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"GQPPEESLYLWIDAHQARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVNVIVMNSEGNTILRTPQNAIFFKTCQQAECPGGCRNGGFCNERRVCECPDGFYGPHCEKALCIPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCREGWHGRHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEDRRDPPESNYIWVEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"39.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":379,"aminoAcidStart":29,"nature":"Recombinant","expressionSystem":"Insect cells","accessionNumber":"Q9WUA1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

WIF1 also known as Wnt inhibitory factor 1 encodes a protein that interacts with Wnt proteins and inhibits their activity. This protein has an approximate molecular mass of 40 kDa and is secreted into the extracellular space. It shows expression in various tissues including the brain lung and kidney. The structure of WIF1 enables it to bind directly to Wnt proteins modulating their signaling capabilities.
Biological function summary

WIF1 participates in the regulation of Wnt signaling which is a critical pathway for cell development and differentiation. It functions to maintain cellular homeostasis by preventing excessive Wnt signaling an essential process in embryonic development and adult tissue maintenance. WIF1 does not form a complex but interacts with Wnt proteins in the extracellular environment ensuring that Wnt signaling remains controlled.

Pathways

WIF1 plays a significant role in the Wnt signaling pathway which is essential for processes like cell fate determination and proliferation. By inhibiting Wnt activity WIF1 supports maintaining balanced signaling levels within the pathway. It connects to other components like β-catenin and can influence pathways like the Wnt/β-catenin signaling pathway which involves the accumulation and transcriptional activity of β-catenin in the cell nucleus.

WIF1 has been implicated in cancer and osteoarthritis due to its regulatory effect on Wnt signaling. Downregulation of WIF1 often associates with increased Wnt activity contributing to tumor progression in various cancers through interactions with proteins like DKK1 a known Wnt pathway inhibitor. In osteoarthritis altered WIF1 expression levels can affect cartilage degradation by modifying Wnt signaling showing its role in maintaining joint health.
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일반 정보

기능

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

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제품 프로토콜

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타겟 정보

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
See full target information Wif1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature neuroscience 22:709-718 PubMed30988524

2019

Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Jianqin Niu,Hui-Hsin Tsai,Kimberly K Hoi,Nanxin Huang,Guangdan Yu,Kicheol Kim,Sergio E Baranzini,Lan Xiao,Jonah R Chan,Stephen P J Fancy
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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