Recombinant Pseudomonas aeruginosa Regulatory protein RhlR (His tag)
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Recombinant Pseudomonas aeruginosa Regulatory protein RhlR (His tag) is a Pseudomonas aeruginosa PAO1 Full Length protein, in the 1 to 241 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
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lasM, vsmR, PA3477, rhlR, HTH-type quorum-sensing regulator RhlR, Elastase modulator, Regulatory protein RhlR, lasM, rhlR, vsmR, Elastase modulator
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Pseudomonas aeruginosa Regulatory protein RhlR (His tag) (AB225569)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab225569 could indicate that this peptide derived from E.coli-expressed Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Regulatory protein RhlR.
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Pseudomonas aeruginosa Regulatory protein RhlR (His tag) (AB225569)
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS analysis result of ab225569 could indicate that this peptide derived from E.coli-expressed Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Regulatory protein RhlR.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Pseudomonas aeruginosa Regulatory protein RhlR (His tag) (AB225569)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab225569 with 5% enrichment gel and 15% separation gel.
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The regulatory protein RhlR controls the transcription of genes involved in the production of rhamnolipids pyocyanin and elastase which contribute to bacterial virulence. RhlR forms a part of the complex interplay between LasR and RhlI which comprise the quorum sensing system. This complex communication network allows the bacteria to modulate its pathogenic behavior and adapt to different environments or host conditions.
Pathways
The regulatory protein RhlR serves a primary function within the quorum sensing pathway of Pseudomonas aeruginosa. It interacts significantly with another quorum sensing protein LasR to regulate a hierarchy of genes responsible for pathogenicity. The pathways involving RhlR are critical for the coordinated expression of virulence factors contributing to biofilm formation and increased bacterial resistance to antibiotics.
일반 정보
기능
Quorum-sensing regulator that controls the expression of multiple virulence factors in response to extracellular signaling molecules called autoinducers (PubMed : 15576196, PubMed : 7494482, PubMed : 8522523). Involved, among others, in the transcriptional regulation of genes that are responsible for rhamnolipid surfactant biosynthesis (PubMed : 14526008, PubMed : 7604006, PubMed : 8144472). Acts by binding to a specific sequence in the rhlAB regulatory region, both in the presence and in the absence of its autoinducer (PubMed : 14526008). In the former case it activates transcription of the promoter, whereas in the latter it acts as a transcriptional repressor (PubMed : 14526008). Also regulates the expression of the rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, by binding to the rml box in the promoter region (PubMed : 22262098). In addition, is involved in the regulation of the production of elastase (lasB) and pyocyanine (PubMed : 7604006, PubMed : 8144472, PubMed : 8522523).
서열 유사성
Belongs to the autoinducer-regulated transcriptional regulatory protein family.
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