Recombinant Rat PDGF AA protein (Active)
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Recombinant Rat PDGF AA protein (Active) is a Rat Full Length protein, in the 86 to 204 aa range, expressed in HEK 293 cells, with >95%, suitable for SDS-PAGE, FuncS.
대체 명칭 보기
Rpa1, Pdgfa, Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide
- FuncS
Supplier Data
Functional Studies - Recombinant Rat PDGF AA protein (Active) (AB288823)
Fully biologically active determined by the dose dependent proliferation of Balb/c 3T3 cells. ED50 ≤3.6 ng/ml, corresponding to a specific activity of 2.8 x 10^5 units/mg.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Rat PDGF AA protein (Active) (AB288823)
SDS-PAGE analysis of ab288823
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PDGF-AA influences cell proliferation migration and differentiation. It acts as a mitogen especially for mesenchymal cells such as fibroblasts and smooth muscle cells. PDGF-AA is often part of a signaling complex where it activates PDGF receptor-alpha (PDGFR-α) leading to autophosphorylation and subsequent activation of downstream effectors. This strengthens tissue development and wound healing processes.
Pathways
PDGF-AA integrates into critical signaling pathways like the PI3K/AKT pathway and the MAPK/ERK pathway. These pathways regulate cell growth and survival. PDGF-AA binds specifically to PDGFR-α which shares importance with other PDGF isoforms such as PDGF-BB in orchestrating cellular responses through similar pathways thereby ensuring precise physiological outcomes.
일반 정보
기능
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
서열 유사성
Belongs to the PDGF/VEGF growth factor family.
타겟 정보
Product promise
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