AB70456

Recombinant S. japonicum GST protein (Tag Free)

Name: Recombinant S. japonicum GST protein (Tag Free) (ab70456) | Abcam
Brand: Abcam Limited
SKU: AB70456
Rating: 4 (1 reviews)

(1 리뷰)

(15 제품이 사용된 논문 )

Recombinant S. japonicum GST protein (Tag Free) is a Schistosoma japonicum Fragment protein, in the 1 to 226 aa range, expressed in Escherichia coli, with >70%, suitable for SDS-PAGE.

1 이미지

SDS-PAGE - Recombinant S. japonicum GST protein (Tag Free) (AB70456)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant S. japonicum GST protein (Tag Free) (AB70456)

SDS-PAGE showing GST at approximately 26kDa.

주요 정보

Purity

>70%

Purified by affinity chromatography

발현 시스템

Escherichia coli

Applications

SDS-PAGE

applications

Biologically active

Accession

P08515-1

Animal free

Carrier free

Species

Schistosoma japonicum

보관 버퍼

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00174% PMSF

storage-buffer

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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서열 정보

[{"linker":null,"sequence":"MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGLEFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVLDIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTHPDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIAWPLQGWQATFGGGDHPPKSDLVPRGSPGIHRD","proteinLength":"Fragment","predictedMolecularWeight":"105 kDa","actualMolecularWeight":null,"aminoAcidEnd":226,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08515","tags":[]}]

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification

배송 시 보관 조건

Dry Ice

적절한 단기 보관 조건

-80°C

적절한 장기 보관 조건

-80°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

False

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

GST or Glutathione S-transferase is an enzyme family known for detoxifying endogenous and exogenous compounds through conjugation with glutathione. GSTs are about 23–28 kDa in size and are expressed in various tissues such as the liver kidneys and lungs. The GST proteins play vital roles in cellular processes and are utilized extensively in molecular biology often tagged to proteins to enhance solubility known as GST-tagged proteins.

Biological function summary

GST enzymes participate in critical cellular detoxification processes enhancing the solubility of toxins. As part of these processes GST enzymes do not function as part of a larger complex but are individual actors within the cell. They facilitate the conjugation reactions fundamental to cellular metabolism and detoxification making them essential for maintaining cellular health.

Pathways

GST enzymes contribute significantly to the metabolic breakdown pathways like the xenobiotic metabolism pathway. This pathway involves proteins such as cytochrome P450 enzymes which often function upstream to modify compounds for further GST action. GSTs are important for efficiently detoxifying potentially harmful substances preventing cellular damage.

GSTs have considerable relevance to cancer where their overexpression can confer drug resistance in tumor cells complicating treatment approaches. Additionally these enzymes connect with proteins such as MDR1 influencing multidrug resistance in cancer therapy. GSTs also relate to asthma where altered GST activity can affect the body's response to oxidative stress highlighting the enzyme's role in inflammatory processes.

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일반 정보

기능

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

서열 유사성

Belongs to the GST superfamily. Mu family.

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제품 프로토콜

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information Glutathione S-transferase class-mu 26 kDa isozyme

대체 명칭 보기

Glutathione S-transferase class-mu 26 kDa isozyme, GST 26, Sj26 antigen, SjGST

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제품이 사용된 논문 (15)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Autophagy 20:1314-1334 PubMed38174993

2024

Targeting cancer-associated fibroblast autophagy renders pancreatic cancer eradicable with immunochemotherapy by inhibiting adaptive immune resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhen Zhang,Mengyi Lao,Hanshen Yang,Kang Sun,Yunfei Dong,Lihong He,Xinchi Jiang,Honghui Wu,Yangwei Jiang,Muchun Li,Honggang Ying,Xinyuan Liu,Jian Xu,Yan Chen,Hanjia Zhang,Ruhong Zhou,Jianqing Gao,Xueli Bai,Tingbo Liang

Nucleic acids research 52:1661-1676 PubMed38084912

2023

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew D Huber,Shyaron Poudel,Jing Wu,Darcie J Miller,Wenwei Lin,Lei Yang,Monicah N Bwayi,Mary Ashley Rimmer,Rebecca R Florke Gee,Jayaraman Seetharaman,Sergio C Chai,Taosheng Chen

International journal of molecular sciences 24: PubMed37298473

2023

Chondrocyte Thrombomodulin Protects against Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Kang,Ai-Lun Yang,Chao-Han Lai,Tsan-Ju Chen,Sung-Yen Lin,Yan-Hsiung Wang,Chau-Zen Wang,Edward M Conway,Hua-Lin Wu,Mei-Ling Ho,Je-Ken Chang,Chung-Hwan Chen,Tsung-Lin Cheng

Cell death and differentiation 30:560-575 PubMed36539510

2022

Targeting ubiquitin-specific protease 8 sensitizes anti-programmed death-ligand 1 immunotherapy of pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hanshen Yang,Xiaozhen Zhang,Mengyi Lao,Kang Sun,Lihong He,Jian Xu,Yi Duan,Yan Chen,Honggang Ying,Muchun Li,Chengxiang Guo,Qingsong Lu,Sicheng Wang,Wei Su,Tingbo Liang,Xueli Bai

Cell reports. Medicine 3:100825 PubMed36513070

2022

β-Defensin 19/119 mediates sperm chemotaxis and is associated with idiopathic infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofeng Li,Chun Yuan,Jianwu Shi,Hang Kang,Yufei Chen,Yonggang Duan,Jing Jin,Lai Ping Cheung,Tin Chiu Li,Ying Liu,Yugui Cui,Ye Chun Ruan,Xiaohua Jiang,Zhiming Cai,Hsiao Chang Chan,Ling Ji,Xuhui Zeng,Jiaying Liu,Hao Chen,Kin Lam Fok

Nature communications 12:4536 PubMed34315872

2021

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaozhen Zhang,Xing Huang,Jian Xu,Enliang Li,Mengyi Lao,Tianyu Tang,Gang Zhang,Chengxiang Guo,Xiaoyu Zhang,Wen Chen,Dipesh Kumar Yadav,Xueli Bai,Tingbo Liang

American journal of translational research 12:5525-5537 PubMed33042435

2020

Tetraspanin CD9 interacts with α-secretase to enhance its oncogenic function in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Lu,Aihua Fei,Ying Jiang,Liang Chen,Yunkun Wang

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 35:1812-1823 PubMed32329910

2020

Thrombomodulin Functional Domains Support Osteoblast Differentiation and Bone Healing in Diabetes in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chung-Hwan Chen,Chao-Han Lai,Yi-Kai Hong,Jui-Ming Lu,Sung-Yen Lin,Tien-Ching Lee,Lan-Yun Chang,Mei-Ling Ho,Edward M Conway,Hua-Lin Wu,Tsung-Lin Cheng

Molecular cell 71:606-620.e7 PubMed30118680

2018

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.

Applications

Unspecified application

Species

Unspecified reactive species

Jong-Ho Cha,Wen-Hao Yang,Weiya Xia,Yongkun Wei,Li-Chuan Chan,Seung-Oe Lim,Chia-Wei Li,Taewan Kim,Shih-Shin Chang,Heng-Huan Lee,Jennifer L Hsu,Hung-Ling Wang,Chu-Wei Kuo,Wei-Chao Chang,Sirwan Hadad,Colin A Purdie,Aaron M McCoy,Shirong Cai,Yizheng Tu,Jennifer K Litton,Elizabeth A Mittendorf,Stacy L Moulder,William F Symmans,Alastair M Thompson,Helen Piwnica-Worms,Chung-Hsuan Chen,Kay-Hooi Khoo,Mien-Chie Hung

Cell death & disease 9:458 PubMed29686263

2018

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wondossen Sime,Qiankun Niu,Yasmin Abassi,Katarzyna Chmielarska Masoumi,Reihaneh Zarrizi,Julie Bonne Køhler,Sven Kjellström,Vito Alessandro Lasorsa,Mario Capasso,Haian Fu,Ramin Massoumi

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Recombinant S. japonicum GST protein (Tag Free)

SDS-PAGE - Recombinant S. japonicum GST protein (Tag Free) (AB70456)

주요 정보

Purity

발현 시스템

Tags

Applications

Biologically active

Accession

Animal free

Carrier free

Species

보관 버퍼

보완 제품

Reagents, Controls & Accessories

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

서열 정보

특성 및 보관 정보

제형

Purification 테크닉

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

일반 정보

기능

서열 유사성

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (15)

Product promise