CCN2
GeneName
CCN2
Summary
CCN2, also known as connective tissue growth factor (CTGF) or CCN-2, is a 38 kDa secreted protein that plays a pivotal role in the extracellular matrix and is expressed in various tissues, including cartilage and skin. It is involved in multiple biological processes such as angiogenesis, cell adhesion, and tissue homeostasis. CCN2 interacts with heparin, insulin-like growth factors, and integrins, facilitating cell-matrix adhesion and promoting chondrocyte differentiation and proliferation. Its presence in the extracellular space underscores its importance in cellular signalling and tissue development.
Importance
CCN2 is relevant to: - Tissue repair and regeneration through its role in cell migration and adhesion - Developmental biology, particularly in cartilage and lung development - Fibrosis and chronic wound healing due to its involvement in extracellular matrix remodelling - Cancer biology, as it can influence tumour growth and metastasis through angiogenic processes
Top Products
For researchers investigating CCN2, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-CTGF antibody (ab5097), which has garnered 23 citations, reflecting its reliability in Western blotting (WB) and immunocytochemistry (ICC). Additionally, we offer the recombinant antibody, Anti-CTGF antibody [EPR20728] (ab209780), which has been validated in a broader range of applications, including WB, ICC, and immunoprecipitation (IP). This recombinant option has received even more attention, with 29 citations, making it a robust choice for those seeking consistency and versatility in their research on CCN2. The Human CTGF ELISA Kit (ab261851), supported by 7 citations, is an excellent option for researchers looking to accurately measure CCN2 levels in their samples.
Abcam Product Citation Summary
The data indicates that CCN2 is being studied in the context of human colorectal cancer and various human tumour cell lines. The use of Western blotting suggests a focus on protein expression levels, particularly in relation to pathways such as YAP1-mediated transcriptional networks and the Hippo pathway.
Abcam Product Citation Table
Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
Involvement in disease
Kyphomelic dysplasia
KMD
An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears.
None
The disease may be caused by variants affecting the gene represented in this entry.
Spondyloepimetaphyseal dysplasia, Li-Shao-Li type
SEMDLSL
A form of spondyloepimetaphyseal dysplasia, a clinically and genetically heterogeneous group of skeletal disorders marked by vertebral, epiphyseal, and metaphyseal abnormalities. SEMDLSL is an autosomal dominant form characterized by childhood onset of defective skeletal development. Affected individuals exhibit disproportionate short stature, short lower limbs, limited joint flexion, premature osteoarthritis-like changes in weight-bearing joints, and low bone mass.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the CCN family.
Tissue Specificity
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
Alternative names
CTGF, HCS24, IGFBP8, CCN2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8
Database links
swissprot:P29279 omim:121009 entrezGene:1490
Other research areas
- Neuroscience