CD83
Function
Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed:21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).
Post-translational modifications
Glycosylated when expressed on activated dendritic cells.
Tissue Specificity
Expressed by activated lymphocytes, Langerhans cells and activatd dendritic cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15