FNDC5
Domain
Fibronectin type-III domain is capable of forming a continuous intersubunit beta-sheet dimer; dimerization may thereby play a role in cell-cell adhesion or signaling.
Function
Irisin
Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
Post-translational modifications
The extracellular domain is cleaved and released from the cell membrane.
N-Glycosylated.
Tissue Specificity
Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.
Cellular localization
- Fibronectin type III domain-containing protein 5
- Cell membrane
- Single-pass membrane protein
- Peroxisome membrane
- Single-pass membrane protein
- Imported into peroxisomes through the PEX5 receptor pathway.
- Irisin
- Secreted
- Detected in plasma following endurance exercise.
Alternative names
FRCP2, FNDC5, Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein 2