Ltbr
Function
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
(Microbial infection) Plays a role in host defense against Zika virus infection.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
Tnfcr, Tnfrsf3, Ltbr, Tumor necrosis factor receptor superfamily member 3, Lymphotoxin-beta receptor