Immunometabolism
Explore how metabolic pathways shape immune cell function and drive immune responses in health and disease.
Tools for immunometabolism research
A practical overview of the key tools and techniques used in immunometabolism research.
Immunometabolism across immune cell types
How metabolic pathways shape immune cell development, differentiation, and function.
Metabolic regulation of the immune system in disease
How metabolic pathways shape immune cell fate and drive inflammation, immune dysfunction, and disease progression across cancer, autoimmunity, and metabolic disorders.
Immunometabolism is the field that examines how intracellular metabolic pathways shape immune cell fate, function, communication, and adaptability, and how systemic metabolism influences immunity in health and disease. It integrates biochemistry, signaling, and immunology to explain how nutrient sensing, metabolite flux, and energy production dictate immune responses across different cell types, tissues, and disease settings.
From glycolysis and mitochondrial metabolism to amino acid sensing, lipid metabolism, and metabolic enzyme expression, these pathways provide valuable readouts of immune cell activation, differentiation, exhaustion, persistence, and tissue adaptation. The resources and tools below support the study of immunometabolic mechanisms across immune cell types, pathways, and disease contexts.
Tools for immunometabolism research
Browse our curated portfolio of Immunometabolism research tools to keep your research moving forward.
Immunometabolism resources
Immunometabolism across immune cell types
Different immune cell types adopt distinct metabolic programs depending on activation state and environmental context. These adaptations allow cells to respond rapidly to infection, maintain tissue homeostasis, or resolve inflammation. Understanding these relationships is essential for studying diseases such as cancer, autoimmunity, and chronic inflammation, and for identifying new therapeutic strategies.
Immunometabolic pathways
Several core pathways recur as decisive regulators of immune function. Each links nutrient sensing to transcriptional, epigenetic, or signaling outputs that shape immunity.
Metabolic regulation of the immune system in disease
Because metabolism and immunity are tightly coupled, metabolic rewiring is a recurring feature of immune-driven disease. Nutrient competition, hypoxia, and altered metabolite pools within diseased tissues remodel immune function in ways that can be exploited therapeutically.
Application notes
Analyzing macrophage metabolism with Met-Flow
Met-Flow–based single-cell analysis enables high-dimensional profiling of macrophage immunometabolism.
Webinars
CAR-T cell therapy for blood cancers: Why metabolism matters
Chimeric antigen receptor (CAR)-T cells are highly effective in treating most cases of Diffuse Large B-Cell Lymphoma (DLBCL); however, only ~30% of patients experience durable, long-term responses. Understanding the cellular underpinnings of why some patients do not respond to CAR-T cell therapy remains critical to developing novel therapeutic strategies for these patients. In this webinar, Dr Ellen King from King’s College London will share insights into how advanced single-cell analysis techniques such as Met-Flow are helping researchers overcome the challenge of mapping dynamic metabolic shifts across highly heterogeneous patient-derived immune cell populations.