• Product name
  • Description
    Rabbit polyclonal to KPNA6
  • Host species
  • Specificity
    ab105350 is predicted to not crossreact with other Importin alpha family members.
  • Tested applications
    Suitable for: ICC/IF, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 13 amino acid peptide from a region within the N terminus of Human KPNA6 (CAH71948).

  • Positive control
    • 293 cell lysate


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab105350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 60 kDa.


  • Function
    Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the importin alpha family.
    Contains 10 ARM repeats.
    Contains 1 IBB domain.
  • Information by UniProt
  • Database links
  • Form
    Cellular location: cytoplasm; nucleus.
  • Alternative names
    • FLJ11249 antibody
    • IMA7_HUMAN antibody
    • Importin alpha 7 subunit antibody
    • Importin alpha S2 antibody
    • Importin subunit alpha 7 antibody
    • Importin subunit alpha-7 antibody
    • IPOA 7 antibody
    • IPOA7 antibody
    • Karyopherin alpha 6 antibody
    • Karyopherin alpha 6 (importin alpha 7) antibody
    • Karyopherin subunit alpha 6 antibody
    • Karyopherin subunit alpha-6 antibody
    • KPNA 6 antibody
    • KPNA 7 antibody
    • Kpna6 antibody
    • KPNA7 antibody
    • MGC17918 antibody
    • OTTHUMP00000004532 antibody
    see all


  • Anti-KPNA6 antibody (ab105350) at 1 µg/ml + 293 cell lysate at 15 µg

    Predicted band size: 60 kDa

  • Immunofluorescence of KPNA6 in 293 cells with ab105350 at 20 ug/mL.
  • Immunofluorescence of KPNA6 in 293 cells using ab105350 at 20 ug/ml.


ab105350 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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I am sending this email to inquire about the updates you might have about the WB analysis. There were few anti KPNA4 products that were proving difficult to use and as per your last email you were suppose to contact m...

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Two SRP1 antibodies failed, which is very strange. We have used SRP1 transfected 293T cells line in the characterization of antibody ab124646, this means that the 293T cells seems not expressing the protein. I would ...

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I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

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We have 3 antibodies ab6035, ab6039 and ab82149 available from the same collaborator as for ab6038, and ab6036. It is hard to guess if these 3 antibodies will perform as good as ab6038/ ab6036 antibodies or even ...

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Thank you very much for filling the questionnaires. I am glad to hear that the antibody ab97505 is working in retest experiment. Because you have not mentioned ab88859 so I am assuming that this antibody is also successful.

I have checked the...

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Thank you for calling us and for alerting us to the problem you are experiencing with our product. We take product complaints very seriously, and investigate every product that we feel may not be performing correctly.

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