Key features and details
- Goat polyclonal to KPNA6
- Suitable for: WB, IHC-P, ELISA
- Reacts with: Human
- Isotype: IgG
Product nameAnti-KPNA6 antibody
See all KPNA6 primary antibodies
DescriptionGoat polyclonal to KPNA6
Tested applicationsSuitable for: WB, IHC-P, ELISAmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog, Pig
- Human adrenal tissue, Human prostate tissue, Human muscle lysate.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab110016 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 60 kDa.|
|IHC-P||Use a concentration of 3.75 µg/ml.|
FunctionFunctions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the importin alpha family.
Contains 10 ARM repeats.
Contains 1 IBB domain.
- Information by UniProt
FormCellular location: cytoplasm; nucleus.
- FLJ11249 antibody
- IMA7_HUMAN antibody
- Importin alpha 7 subunit antibody
ab110016, at 3.75 µg/ml, staining KPNA6 in Human adrenal tissue by immunohistochemistry.
ab110016, at 3.75 µg/ml, staining KPNA6 in Human prostate tissue by immunohistochemistry.
Anti-KPNA6 antibody (ab110016) at 0.1 µg/ml + Human muscle lysate (in RIPA buffer) at 35 µg
Predicted band size: 60 kDa
Primary incubation was 1 hour. Detected by chemiluminescence.
ab110016 has not yet been referenced specifically in any publications.