Overview

  • Product name

    Anti-KRT86 antibody - C-terminal
  • Description

    Guinea pig polyclonal to KRT86 - C-terminal
  • Host species

    Guinea pig
  • Specificity

    ab192754 stains specifically hair KRT86 expressed starting from the middle hair cortex. It can be defect in Monilethrix.
  • Tested applications

    Suitable for: IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human KRT86 aa 446-469 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH) (Cysteine residue).
    Sequence:

    APVVSTRVSSVPSNSNVVVGTTNA


    Database link: O43790

Properties

Applications

Our Abpromise guarantee covers the use of ab192754 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/200.

For enhancement of cortex staining preincubate fixed sections with 0.1 Triton X-100 (in PBS) for 1 - 5 min prior to first antibody incubation step.

WB 1/2000. Predicted molecular weight: 54 kDa.

Detect using ECL

Target

  • Tissue specificity

    Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
  • Involvement in disease

    Defects in KRT86 are a cause of monilethrix (MLTRX) [MIM:158000]. Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.
  • Sequence similarities

    Belongs to the intermediate filament family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Hair keratin K2.11 antibody
    • Hb6 antibody
    • K86 antibody
    • Keratin antibody
    • Keratin-86 antibody
    • KRT86 antibody
    • KRT86_HUMAN antibody
    • KRTHB6 antibody
    • MNX antibody
    • type II cuticular Hb6 antibody
    • Type II hair keratin Hb6 antibody
    • Type-II keratin Kb26 antibody
    see all

References

ab192754 has not yet been referenced specifically in any publications.

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