Overview

  • Product name

    KT5720, protein kinase A inhibitor
  • Description

    Potent, selective protein kinase A inhibitor
  • Biological description

    Potent, selective protein kinase A (Ki = 60 nM) inhibitor . Reversibly arrests human skin fibroblasts in the G1 phase. Cell permeable.
  • Purity

    > 98%
  • CAS Number

    108068-98-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4- i][1,6]benzodiazocine-10-carboxylic acid hexyl ester
  • Molecular weight

    537.61
  • Molecular formula

    C32H31N3O5
  • PubChem identifier

    454202
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
  • Source

    Synthetic

  • Research areas

Images

  • KT5720 inhibits PKAS phosphorylation via PKA.

    NIH/C6 cells were preincubated for 45 min with different concentrations of KT5720 (ab141818) and then stimulated with 10 µM Forskolin (ab120058) for 20 min. Cell proteins were resolved by SDS-PAGE and probed with antiphospho-(Ser/Thr) PKAS (PKA substrate).

References

This product has been referenced in:

  • Wolf ME  et al. Mechanisms by which dopamine receptors may influence synaptic plasticity. Ann N Y Acad Sci 1003:241-9 (2003). Read more (PubMed: 14684450) »
  • Olsen MK  et al. KT5720 and U-98017 inhibit MAPK and alter the cytoskeleton and cell morphology. J Cell Physiol 176:525-36 (1998). Read more (PubMed: 9699505) »
  • Abraham I  et al. K252a, KT5720, KT5926, and U98017 support paclitaxel (taxol)-dependent cells and synergize with paclitaxel. Cancer Res 54:5889-94 (1994). Read more (PubMed: 7954419) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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