Overview

  • Product name

    KT5823, inhibitor of PKG
  • Description

    Potent, selective inhibitor of PKG
  • Biological description

    Potent, selective, reversible inhibitor of Protein Kinase G (PKG) (Ki = 234 nM). Derivative of K252, selective over PKA and PKC (Ki values are >10 and 4 μM, respectively). Prevents increased phosphorylation of regulators of G-protein-signalling in vivo.
  • Purity

    > 95%
  • CAS Number

    126643-37-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
  • Molecular weight

    495.53
  • Molecular formula

    C29H25N3O5
  • PubChem identifier

    108152
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 2.5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(OC)[C@]8(C[C@H]7O[C@]8(C)n4c3c1n7c6ccccc6c1c2c(CN(C)C2=O)c3c5ccccc45)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chan SL & Fiscus RR Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG. Mol Hum Reprod 9:775-83 (2003). Read more (PubMed: 14614039) »
  • Burkhardt M  et al. KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells. J Biol Chem 275:33536-41 (2000). Read more (PubMed: 10922374) »
  • Levander-Lindgren M ECG telemetry for pacemaker check-up. Acta Med Scand Suppl 596:72-6 (1976). Read more (PubMed: 1070230) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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