Overview

  • Product name

    KU 0063794, mTOR inhibitor
  • Description

    Potent and selective mTOR inhibitor
  • Biological description

    Potent mTOR inhibitor (mTORC1 & mTOTC2 IC50 = 10 nM). Highly selective against a panel of 76 protein kinases and 7 lipid kinases. Inhibits activation of Akt, S6K and SGK. Suppresses cell growth and induces G1 cell cycle arrest in vitro

  • Purity

    > 98%
  • General notes

    Protect from air and light.

  • CAS Number

    938440-64-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
  • Molecular weight

    465.55
  • Molecular formula

    C25H31N5O4
  • PubChem identifier

    16736978
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
  • Source

    Synthetic

References

This product has been referenced in:

  • Yongxi T  et al. Autophagy inhibition sensitizes KU-0063794-mediated anti-HepG2 hepatocellular carcinoma cell activity in vitro and in vivo. Biochem Biophys Res Commun 465:494-500 (2015). Read more (PubMed: 26278819) »
See all 2 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120667.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up