Overview

  • Product name

    KU-60019, ATM kinase inhibitor
  • Description

    Potent, highly selective ATM kinase inhibitor
  • Biological description

    Potent, highly selective ATM kinase inhibitor (IC50 = 6.3 nM). Inhibits migration and invasion of glioma cells. Shows similar target selectivity to KU-55933 (ab120637). Shows radiosensitizing effects in vivo.
  • Purity

    > 99%
  • CAS Number

    925701-49-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Vecchio D  et al. Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019. Int J Cancer 135:479-91 (2014). Read more (PubMed: 24443327) »
  • Biddlestone-Thorpe L  et al. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clin Cancer Res 19:3189-200 (2013). Read more (PubMed: 23620409) »
  • Gamper AM  et al. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. J Biol Chem 287:12445-54 (2012). Read more (PubMed: 22362778) »
See all 2 Publications for this product

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