Anti-Kv1.4/RK3 antibody (ab191052)
Key features and details
- Rabbit polyclonal to Kv1.4/RK3
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-Kv1.4/RK3 antibody
See all Kv1.4/RK3 primary antibodies -
Description
Rabbit polyclonal to Kv1.4/RK3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Human
Predicted to work with: Mouse, Cow -
Immunogen
Synthetic peptide corresponding to Human Kv1.4/RK3 aa 300-400 (internal sequence).
Database link: P22459 -
Positive control
- Rat brain tissue lysate; HY1080, PANC, U87 and SHG cell lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191052 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 73 kDa.
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Notes |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 73 kDa. |
Target
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Function
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. -
Sequence similarities
Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. -
Domain
The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 281880 Cow
- Entrez Gene: 3739 Human
- Entrez Gene: 16492 Mouse
- Entrez Gene: 25469 Rat
- Omim: 176266 Human
- SwissProt: Q05037 Cow
- SwissProt: P22459 Human
- SwissProt: Q61423 Mouse
see all -
Alternative names
- Voltage gated K+ channel HuKII antibody
- Fetal skeletal muscle potassium channel antibody
- HBK4 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab191052 has been referenced in 2 publications.
- Suda M et al. Adult-onset hypothyroidism causes mechanical hypersensitivity due to peripheral nerve hyperexcitability based on voltage-gated potassium channel downregulation in male mice. J Neurosci Res 100:506-521 (2022). PubMed: 34935172
- Wang Y et al. Contribution of potassium channels to action potential repolarization of human embryonic stem cell-derived cardiomyocytes. Br J Pharmacol 176:2780-2794 (2019). PubMed: 31074016