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    kv42kcnd2-antibody-ab16719.pdf

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Neuroscience Neurotransmission Receptors / Channels Potassium Channels
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Anti-Kv4.2/KCND2 antibody (ab16719)

  • Datasheet
  • SDS
Reviews (2) Submit a question References (4)

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Key features and details

  • Rabbit polyclonal to Kv4.2/KCND2
  • Reacts with: Rat
  • Isotype: IgG

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Overview

  • Product name

    Anti-Kv4.2/KCND2 antibody
    See all Kv4.2/KCND2 primary antibodies
  • Description

    Rabbit polyclonal to Kv4.2/KCND2
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Rat
  • Immunogen

    Synthetic peptide corresponding to Rat Kv4.2/KCND2 aa 453-470 conjugated to keyhole limpet haemocyanin.
    Database link: Q63881

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.40
    Preservative: 0.08% Sodium azide
    Constituent: PBS
  • Concentration information loading...
  • Purity

    Ammonium Sulphate Precipitation
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Potassium Channels
    • Cardiovascular
    • Heart
    • Cardiac arrhythmias

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Function

    Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
  • Tissue specificity

    Highly expressed throughout the brain. Expression is very low or absent in other tissues.
  • Sequence similarities

    Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.
  • Domain

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • Post-translational
    modifications

    Phosphorylated on serine and threonine residues.
  • Cellular localization

    Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.
  • Target information above from: UniProt accession Q9NZV8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 65180 Rat
    • SwissProt: Q63881 Rat
    • Unigene: 87841 Rat
    • Alternative names

      • KCD2 antibody
      • KCND 2 antibody
      • KCND2 antibody
      • KCND2_HUMAN antibody
      • KIAA1044 antibody
      • MGC119702 antibody
      • MGC119703 antibody
      • Potassium voltage gated channel Shal related subfamily member 2 antibody
      • Potassium voltage-gated channel subfamily D member 2 antibody
      • RK 5 antibody
      • RK5 antibody
      • Voltage gated potassium channel Kv4.2 antibody
      • Voltage gated potassium channel subunit Kv4.2 antibody
      • Voltage sensitive potassium channel antibody
      • Voltage-gated potassium channel subunit Kv4.2 antibody
      see all

    Protocols

    • Immunoprecipitation protocols
    • Immunocytochemistry & immunofluorescence protocols
    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (4)

    Publishing research using ab16719? Please let us know so that we can cite the reference in this datasheet.

    ab16719 has been referenced in 4 publications.

    • Yao J  et al. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not ß-Amyloid Accumulation. Cell Rep 32:108169 (2020). PubMed: 32966798
    • Yang CH  et al. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. J Neurosci 32:7550-62 (2012). PubMed: 22649233
    • Noam Y  et al. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem 285:14724-36 (2010). WB ; Rat . PubMed: 20215108
    • Stones R  et al. The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts. Basic Res Cardiol 104:643-52 (2009). WB ; Rat . PubMed: 19415411

    Customer reviews and Q&As

    Show All Reviews Q&A
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    1-2 of 2 Abreviews or Q&A

    ELISA abreview for Anti-Kv4.2/KCND2 antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    ELISA
    Sample
    Rat Purified protein (neuronal)
    Specification
    neuronal
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 1% · Temperature: 18°C
    Type
    Indirect
    Read More

    Abcam user community

    Verified customer

    Submitted May 06 2009

    Western blot abreview for Anti-Kv4.2/KCND2 antibody

    Good
    Abreviews
    Abreviews
    abreview image
    Application
    Western blot
    Sample
    Escherichia coli Purified protein (E.Coli)
    Gel Running Conditions
    Reduced Denaturing (gradient 4-12%)
    Loading amount
    0.05 µg
    Specification
    E.Coli
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 4°C
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 09 2009

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