Anti-Kv4.2/KCND2 antibody (ab16719)
Key features and details
- Rabbit polyclonal to Kv4.2/KCND2
- Reacts with: Rat
- Isotype: IgG
Overview
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Product name
Anti-Kv4.2/KCND2 antibody
See all Kv4.2/KCND2 primary antibodies -
Description
Rabbit polyclonal to Kv4.2/KCND2 -
Host species
Rabbit -
Species reactivity
Reacts with: Rat -
Immunogen
Synthetic peptide corresponding to Rat Kv4.2/KCND2 aa 453-470 conjugated to keyhole limpet haemocyanin.
Database link: Q63881
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.08% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Ammonium Sulphate Precipitation -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. -
Tissue specificity
Highly expressed throughout the brain. Expression is very low or absent in other tissues. -
Sequence similarities
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily. -
Domain
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. -
Post-translational
modificationsPhosphorylated on serine and threonine residues. -
Cellular localization
Cell membrane. Cell projection > dendrite. Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression. - Information by UniProt
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Database links
- Entrez Gene: 65180 Rat
- SwissProt: Q63881 Rat
- Unigene: 87841 Rat
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Alternative names
- KCD2 antibody
- KCND 2 antibody
- KCND2 antibody
see all
Protocols
References (4)
ab16719 has been referenced in 4 publications.
- Yao J et al. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not ß-Amyloid Accumulation. Cell Rep 32:108169 (2020). PubMed: 32966798
- Yang CH et al. A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes. J Neurosci 32:7550-62 (2012). PubMed: 22649233
- Noam Y et al. Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem 285:14724-36 (2010). WB ; Rat . PubMed: 20215108
- Stones R et al. The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts. Basic Res Cardiol 104:643-52 (2009). WB ; Rat . PubMed: 19415411
