- References (7)
Product nameKynurenic acid sodium salt, Endogenous ionotropic / nicotinic antagonist
DescriptionEndogenous ionotropic / nicotinic antagonist; water soluble
Biological descriptionEndogenous antagonist at ionotropic, glycine and α7 nicotinic receptors. Neuroprotective in vivo. Water soluble form.
Also available in simple stock solutions (ab146693) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name4-Hydroxyquinoline-2-carboxylic acid sodium salt
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Broad spectrum / non-selective
This product has been referenced in:
- Grilli M et al. Modulation of the function of presynaptic alpha7 and non-alpha7 nicotinic receptors by the tryptophan metabolites, 5-hydroxyindole and kynurenate in mouse brain. Br J Pharmacol 149:724-32 (2006). Read more (PubMed: 17016503) »
- Pittaluga A et al. The "kynurenate test", a biochemical assay for putative cognition enhancers. J Pharmacol Exp Ther 283:82-90 (1997). Read more (PubMed: 9336311) »
- Hicks RR et al. Kynurenate is neuroprotective following experimental brain injury in the rat. Brain Res 655:91-6 (1994). Read more (PubMed: 7812795) »