Overview

  • Product name

    Anti-kynurenine 3-monooxygenase antibody
    See all kynurenine 3-monooxygenase primary antibodies
  • Description

    Rabbit polyclonal to kynurenine 3-monooxygenase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within N-terminal amino acids 13-62 (VIGGGLVGSL QACFLAKRNF QIDVYEARED TRVATFTRGR SINLALSHRG) of Human kynurenine 3-monooxygenase (NP_003670).

  • Positive control

    • OVCAR-3 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab130959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 56 kDa.

Target

  • Function

    Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
  • Tissue specificity

    Highest levels in placenta and liver. Detectable in kidney.
  • Pathway

    Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
  • Sequence similarities

    Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
  • Cellular localization

    Mitochondrion outer membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • dJ317G22.1 antibody
    • kmo antibody
    • KMO_HUMAN antibody
    • Kynurenine 3 hydroxylase antibody
    • Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase) antibody
    • Kynurenine 3 monooxygenase antibody
    • Kynurenine 3-hydroxylase antibody
    • Kynurenine 3-monooxygenase antibody
    • RP1-317G22.1 antibody
    see all

Images

  • Anti-kynurenine 3-monooxygenase antibody (ab130959) at 1 µg/ml + OVCAR-3 cell lysate at 10 µg

    Predicted band size: 56 kDa



    12% SDS PAGE

References

This product has been referenced in:

  • Im EJ  et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun 10:1387 (2019). Read more (PubMed: 30918259) »
See 1 Publication for this product

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