Anti-kynurenine 3-monooxygenase antibody (ab220922)
Key features and details
- Rabbit polyclonal to kynurenine 3-monooxygenase
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-kynurenine 3-monooxygenase antibody
See all kynurenine 3-monooxygenase primary antibodies -
Description
Rabbit polyclonal to kynurenine 3-monooxygenase -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Pig -
Immunogen
Recombinant fragment corresponding to Human kynurenine 3-monooxygenase aa 200-350.
Database link: O15229 -
Positive control
- Human kidney tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab220922 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. -
Tissue specificity
Highest levels in placenta and liver. Detectable in kidney. -
Pathway
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. -
Sequence similarities
Belongs to the aromatic-ring hydroxylase family. KMO subfamily. -
Cellular localization
Mitochondrion outer membrane. - Information by UniProt
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Database links
- Entrez Gene: 8564 Human
- Entrez Gene: 397148 Pig
- Omim: 603538 Human
- SwissProt: O15229 Human
- SwissProt: Q9MZS9 Pig
- Unigene: 725604 Human
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Alternative names
- dJ317G22.1 antibody
- kmo antibody
- KMO_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab220922 has not yet been referenced specifically in any publications.