L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor (ab146130)

Overview

  • Product name

    L-(-)-threo-3-Hydroxyaspartic acid, EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
  • Description

    Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
  • Biological description

    Potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Potentiates L-glutamate (ab120049) and L-aspartate induced neuronal excitation. Shows neuronal excitotoxic effects in vivo.
  • Purity

    > 97%
  • CAS Number

    7298-99-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S)-3-Hydroxy-L-aspartic acid
  • Molecular weight

    149.10
  • Molecular formula

    C4H7NO5
  • PubChem identifier

    443239
  • Storage instructions

    Store at room temperature.
  • Solubility overview

    Soluble in 1eq. NaOH to 100 mM
  • Handling

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    [C@H]([C@@H](C(=O)O)O)(C(=O)O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Hara R  et al. One-Pot Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-Deficient Escherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolor A3(2). Appl Environ Microbiol 81:3648-54 (2015). Read more (PubMed: 25795668) »
  • Nakamura Y  et al. (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32:833-7 (1993). Read more (PubMed: 7901789) »
  • McBean GJ & Roberts PJ Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J Neurochem 44:247-54 (1985). Read more (PubMed: 2856883) »

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