Overview

  • Product name

    L-161,982, EP4 receptor antagonist
  • Description

    Potent and selective EP4 receptor antagonist
  • Biological description

    Potent EP4 receptor antagonist, selective over all other prostanoid receptor family members (Ki values for human receptors are 0.024 (EP4), 0.71 (TP), 1.90 (EP3), 5.10 (DP), 5.63 (FP), 6.74 (IP), 19 (EP1) and 23 μM ( EP2)). Shows a variety of biological actions including suppression of PGE2 stimulated bone formation, blocking of cell proliferation and also reverses anti-inflammatory action of PGE2.
  • Purity

    > 98%
  • CAS Number

    147776-06-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Oliva P  et al. Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. Eur J Pharmacol 530:40-7 (2006). Read more (PubMed: 16360148) »
  • Balzary RW & Cocks TM Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2. J Pharmacol Exp Ther 317:806-12 (2006). Read more (PubMed: 16464966) »
  • Machwate M  et al. Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2). Mol Pharmacol 60:36-41 (2001). Read more (PubMed: 11408598) »

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