Overview

  • Product name

    L-745870 trihydrochloride, brain penetrant D4 antagonist
  • Description

    Highly potent, selective brain penetrant D4 antagonist
  • Biological description

    Highly potent and selective D4 antagonist (Ki values are 0.43, 2300 and 960 nM at D4, D3 and D2, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
  • Purity

    > 99%
  • CAS Number

    866021-03-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Tanaka K  et al. A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice. Exp Neurol 211:378-86 (2008). Read more (PubMed: 18423451) »
  • Mamiya T  et al. Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in mice. Ann N Y Acad Sci 1025:424-9 (2004). Read more (PubMed: 15542745) »
  • Patel S  et al. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. J Pharmacol Exp Ther 283:636-47 (1997). Read more (PubMed: 9353380) »

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