L-alpha-Phosphatidylinositol-3,4,5-trisphosphate sodium salt, PKC delta, epsilon and eta activator (ab145221)

Overview

  • Product name

    L-alpha-Phosphatidylinositol-3,4,5-trisphosphate sodium salt, PKC delta, epsilon and eta activator
  • Description

    Ca2+-insensitive PKC δ, ε and η activator
  • Alternative names

    • 1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate
    • PtdIns(3,4,5)P3
  • Biological description

    Activates Ca2+-insensitive PKC isotypes δ, ε and η in vitro. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain.

  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate sodium salt
  • Molecular weight

    1204.80
  • Molecular formula

    C41H75Na7O22P4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Klarlund JK  et al. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-30 (1997). Read more (PubMed: 9072969) »
  • Toker A  et al. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem 270:29525-31 (1995). Read more (PubMed: 7493994) »
  • Toker A  et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem 269:32358-67 (1994). Read more (PubMed: 7798235) »

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