Product nameL-alpha-Phosphatidylinositol-3,4,5-trisphosphate sodium salt, PKC delta, epsilon and eta activator
DescriptionCa2+-insensitive PKC δ, ε and η activator
Activates Ca2+-insensitive PKC isotypes δ, ε and η in vitro. Binds to the general receptor for phosphoinositide-1 (GRP1) protein through a plekstrin homology (PH) domain.
Chemical name1,2-Dipalmitoyl-sn-glycero-3-phospho-1-D-myo-inositol-3,4,5-trisphosphate sodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Klarlund JK et al. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275:1927-30 (1997). Read more (PubMed: 9072969) »
- Toker A et al. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem 270:29525-31 (1995). Read more (PubMed: 7493994) »
- Toker A et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. J Biol Chem 269:32358-67 (1994). Read more (PubMed: 7798235) »