Overview

  • Product name
    L-AP4, group III mGlu agonist
  • Description
    Selective group III mGlu agonist
  • Biological description
    Selective group III mGlu receptor agonist.

    Also available in simple stock solutions (ab144481) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Schoepp DD  et al. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-76 (1999). Read more (PubMed: 10530808) »
  • Tones MA  et al. The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain. Neuroreport 7:117-20 (1995). Read more (PubMed: 8742431) »
  • Evans RH  et al. The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br J Pharmacol 75:65-75 (1982). Read more (PubMed: 7042024) »
See all 18 Publications for this product

Customer reviews and Q&As

Answer

Thank you for your enquiry regarding L-AP4 and cis-PDA. The lab send me the following information:

As we do not currently undertake any of our own research we can only offer advice based on published literature. Both L-AP4 and cis-PDA have been previously dissolved in PBS for use in both rats and rabbits, respectively. It is therefore reasonable to believe that you will be able to use both compounds with PBS in your research. I have attached two papers for your reference.
I can also provide the following information in reference to neutralizing solutions using 1M NaOH.

L-AP4
5.46 μl (1 mg)
54.6 μl (10 mg)
273.07 μl (50 mg)

cis-PDA
288.73 μl (50 mg)
1.44 ml (250 mg)


These values can be calculated using the following formula:
{ Mass of compound (mg) x 1000 } / { MW of compound x [NaOH] } = Vol (ml) NaOH
In reference to your third point, unfortunately we have not come across previous literature describing a combination of the two compounds used as a cocktail. Since we do not test these combinations in-house I cannot guarantee any in vivo responses, however it is likely that at reasonable physiological concentrations you should see no adverse effects. Please note that you will need to add enough NaOH to neutralize both compounds.
Please do not hesitate to contact us again if you require further assistance.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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