Product nameL-Arginine hydrochloride, Nitrogen donor for synthesis of nitric oxide
DescriptionNitrogen donor for the synthesis of nitric oxide
- (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
- (S)-(+)-Arginine hydrochloride
- Arginine hydrochloride
Substrate of nitric oxide synthase (NOS), which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.
Chemical name(S)-2-Amino-5-guanidinopentanoic acid hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Morris CR et al. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 168:63-9 (2003). Read more (PubMed: 12626350) »
- Yamada M et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab 20:709-17 (2000). Read more (PubMed: 10779015) »
- Vergnani L et al. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production : key role of L-arginine availability. Circulation 101:1261-6 (2000). Read more (PubMed: 10725285) »
- Thams P & Capito K L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide. Eur J Endocrinol 140:87-93 (1999). Read more (PubMed: 10037257) »
- Huk I et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation 96:667-75 (1997). Read more (PubMed: 9244241) »