Overview

  • Product name

    L-erythro-Sphingosine, Sphingosine isomer
  • Description

    Inactive isomer of Sphingosine
  • Biological description

    Inactive isomer of Sphingosine (ab142297). Competitively inhibits Sphingosine as a ceramidase substrate. Induces dephosphorylation of pRb protein (EC50 = 5 μM).
  • Purity

    > 98%
  • CAS Number

    6036-75-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • El Bawab S  et al. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem 276:16758-66 (2001). Read more (PubMed: 11278489) »
  • Pushkareva M  et al. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry 34:1885-92 (1995). Read more (PubMed: 7849048) »
  • Shoyama Y  et al. Total synthesis of stereospecific sphingosine and ceramide. J Lipid Res 19:250-9 (1978). Read more (PubMed: 632688) »

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