Product nameL-Mimosine, non-protein amino acid
DescriptionNon-protein amino acid that acts as an iron chelator.
Toxic non-protein amino acid originally isolated from Mimosa pudica. Arrests the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. Blocks cell cycle progression by chelating iron in asynchronous MDA-MB-453 human breast cancer cells. Arrests DNA synthesis by inhibiting deoxyribonucleotide metabolism. Prolyl hydroxylase (PHD) inhibitor stimulating VEGF production, and increasing proangiogenic capacity in dental pulp-derived cells.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Chung LC et al. L-Mimosine blocks cell proliferation via upregulation of B-cell translocation gene 2 and N-myc downstream regulated gene 1 in prostate carcinoma cells. Am J Physiol Cell Physiol 302:C676-85 (2012). Read more (PubMed: 22116304) »
- Müller HD et al. Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells. J Endod 38:1498-503 (2012). Read more (PubMed: 23063224) »
- Krude T Mimosine arrests proliferating human cells before onset of DNA replication in a dose-dependent manner. Exp Cell Res 247:148-59 (1999). Read more (PubMed: 10047457) »
- Kulp KS & Vulliet PR Mimosine blocks cell cycle progression by chelating iron in asynchronous human breast cancer cells. Toxicol Appl Pharmacol 139:356-64 (1996). Read more (PubMed: 8806853) »
- Gilbert DM et al. Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism. J Biol Chem 270:9597-606 (1995). Read more (PubMed: 7721891) »
- Hashiguchi H & Takahashi H Inhibition of two copper-containing enzymes, tyrosinase and dopamine beta-hydroxylase, by L-mimosine. Mol Pharmacol 13:362-7 (1977). Read more (PubMed: 404519) »