L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine), thyroid prohormone (T4) (ab143720)

Overview

  • Product name

    L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine), thyroid prohormone (T4)
  • Description

    Blood-brain barrier permeable thyroid prohormone (T4)
  • Alternative names

    • Sodium levothyroxine
  • Biological description

    Blood-brain barrier permeable thyroid prohormone (T4). Stimulates metabolic rate. Regulates growth and development. Lowers TSH levels. Orally active.
  • Purity

    > 97%
  • CAS Number

    6106-07-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate sodium salt pentahydrate
  • Molecular weight

    888.93
  • Molecular formula

    C15H20I4NNaO9
  • PubChem identifier

    23665037
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)[O-])N.O.O.O.O.O.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mayerl S  et al. Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. J Clin Invest 124:1987-99 (2014). Read more (PubMed: 24691440) »
  • Sechman A The role of thyroid hormones in regulation of chicken ovarian steroidogenesis. Gen Comp Endocrinol 190:68-75 (2013). Read more (PubMed: 23631902) »
  • Karp WB  et al. The effect of hydrocortisone, thyroxine, and phenobarbital on diamine oxidase activity in newborn rat intestine. Pediatr Res 21:368-70 (1987). Read more (PubMed: 3106923) »

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