Anti-L2HGDH antibody (ab230194)

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Overview

  • Product name

    Anti-L2HGDH antibody
    See all L2HGDH primary antibodies

  • Description

    Rabbit polyclonal to L2HGDH

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Orangutan

  • Immunogen

    Recombinant fragment corresponding to Human L2HGDH aa 1-120.
    Sequence:

    MVPALRYLVGACGRARGLFAGGSPGACGFASGRPRPLCGGSRSASTSSFD IVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSG IYYKPESLKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQ ALYEKGLQNGVPGLRLIQQEDIKKKEPYCRGLMAIDCPHTGIVDYRQVAL SFAQDFQEAGGSVLTNFEVK


    Database link: Q9H9P8

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • IHC-P: Human testis tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab230194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Tissue specificity

    Widely expressed. Highly expressed in brain, testis and muscle. Expressed to a lower extent in lymphocytes, fibroblasts, keratinocytes, placenta, bladder, small intestine, liver and bone marrow.

  • Involvement in disease

    Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA) [MIM:236792]. L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid.

  • Sequence similarities

    Belongs to the L2HGDH family.

  • Cellular localization

    Mitochondrion.
  • Information by UniProt

  • Database links

    • Alternative names

      • 2 hydroxyglutarate dehydrogenase antibody
      • Alpha hydroxyglutarate oxidoreductase antibody
      • Alpha ketoglutarate reductase antibody
      • C14orf160 antibody
      • Duranin antibody
      • FLJ12618 antibody
      • L alpha hydroxyglutarate dehydrogenase antibody
      • L-2-hydroxyglutarate dehydrogenase antibody
      • L-2-hydroxyglutarate dehydrogenase, mitochondrial antibody
      • L2HDH_HUMAN antibody
      • l2hgdh antibody
      • mitochondrial antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L2HGDH antibody (ab230194)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-L2HGDH antibody (ab230194)

      Paraffin-embedded human testis tissue stained for L2HGDH using ab230194 at 1/100 dilution in immunohistochemical analysis.

    References

    ab230194 has not yet been referenced specifically in any publications.

    Publishing research using ab230194? Please let us know so that we can cite the reference in this datasheet.

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