Overview

  • Product name

    Lactacystin, proteasome inhibitor
  • Description

    Cell-permeable, potent and selective proteasome inhibitor
  • Biological description

    Potent, irreversible, cell-permeable, selective 20S proteasome inhibitor (IC50 = 70 nM). Inhibits cell-cycle progression and induces neurite outgrowth in vitro. Anti-bacterial and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 95%
  • CAS Number

    133343-34-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang H  et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res 41:72-81 (2013). Read more (PubMed: 23569132) »
  • Beck J  et al. Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors. Bioorg Med Chem 20:819-31 (2012). Read more (PubMed: 22206869) »
  • Fenteany G  et al. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A 91:3358-62 (1994). Read more (PubMed: 8159752) »
See all 2 Publications for this product

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