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Tags & Cell Markers Subcellular Markers Nucleus Nuclear Envelope
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Anti-Lamin B Receptor/LBR antibody (ab223013)

  • Datasheet
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)
  • Western blot - Anti-Lamin B Receptor/LBR antibody (ab223013)

Key features and details

  • Rabbit polyclonal to Lamin B Receptor/LBR
  • Suitable for: IHC-P, WB
  • Reacts with: Mouse, Human
  • Isotype: IgG

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Protein
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Recombinant Human Lamin B Receptor/LBR protein (ab132387)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Lamin B Receptor/LBR antibody
    See all Lamin B Receptor/LBR primary antibodies
  • Description

    Rabbit polyclonal to Lamin B Receptor/LBR
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human Lamin B Receptor/LBR aa 20-70 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q14739

  • Positive control

    • IHC-P: Mouse embryo tissue; Human lung carcinoma tissue. WB: Jurkat cell lysate
  • General notes

     This product was previously labelled as Lamin B Receptor

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.09% Sodium azide
    Constituents: 1% BSA, 50% Glycerol
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Tags & Cell Markers
    • Subcellular Markers
    • Nucleus
    • Nuclear Envelope
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Intermediate Filaments
    • Class V
    • Lamins
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Lamin B Receptor/LBR protein (ab132387)
  • Related Products

    • Recombinant Human Lamin B Receptor/LBR protein (ab132387)

Applications

Our Abpromise guarantee covers the use of ab223013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.
WB 1/1000. Predicted molecular weight: 71 kDa.

Target

  • Function

    Anchors the lamina and the heterochromatin to the inner nuclear membrane.
  • Involvement in disease

    Defects in LBR are a cause of Pelger-Huet anomaly (PHA) [MIM:169400]. PHA is an autosomal dominant inherited abnormality of neutrophils, characterized by reduced nuclear segmentation and an apparently looser chromatin structure. Heterozygotes show hypolobulated neutrophil nuclei with coarse chromatin. Presumed homozygous individuals have ovoid neutrophil nuclei, as well as varying degrees of developmental delay, epilepsy, and skeletal abnormalities.
    Defects in LBR are the cause of hydrops-ectopic calcification-moth-eaten skeletal dysplasia (HEM) [MIM:215140]; also known as Greenberg skeletal dysplasia. HEM is a rare autosomal recessive chondrodystrophy characterized by early in utero lethality and, therefore, considered to be nonviable. Affected fetuses typically present with fetal hydrops, short-limbed dwarfism, and a marked disorganization of chondro-osseous calcification and may present with polydactyly and additional nonskeletal malformations.
    Defects in LBR may be a cause of Reynolds syndrome (REYNS) [MIM:613471]. It is a syndrome specifically associating limited cutaneous systemic sclerosis and primary biliray cirrhosis. It is characterized by liver disease, telangiectasia, abrupt onset of digital paleness or cyanosis in response to cold exposure or stress (Raynaud phenomenon), and variable features of scleroderma. The liver disease is characterized by pruritis, jaundice, hepatomegaly, increased serum alkaline phosphatase and positive serum mitochondrial autoantibodies, all consistent with primary biliary cirrhosis.
  • Sequence similarities

    Belongs to the ERG4/ERG24 family.
  • Post-translational
    modifications

    Phosphorylated by CDK1 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle.
  • Cellular localization

    Nucleus inner membrane.
  • Target information above from: UniProt accession Q14739 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 3930 Human
    • Entrez Gene: 98386 Mouse
    • Omim: 600024 Human
    • SwissProt: Q14739 Human
    • SwissProt: Q3U9G9 Mouse
    • Unigene: 435166 Human
    • Unigene: 4538 Mouse
    • Alternative names

      • DHCR 14B antibody
      • DHCR14B antibody
      • Integral nuclear envelope inner membrane protein antibody
      • Lamin-B receptor antibody
      • LBR antibody
      • LBR_HUMAN antibody
      • LMN 2R antibody
      • LMN2R antibody
      • MGC9041 antibody
      • PHA antibody
      • PRO0650 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)

      Formalin-fixed, paraffin-embedded mouse embryo tissue stained for Lamin B Receptor/LBR with ab223013 at 1/200 dilution in immunohistochemical analysis. DAB staining.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lamin B Receptor/LBR antibody (ab223013)

      Formalin-fixed, paraffin-embedded human lung carcinoma tissue stained for Lamin B Receptor/LBR with ab223013 at 1/200 dilution in immunohistochemical analysis. DAB staining.

    • Western blot - Anti-Lamin B Receptor/LBR antibody (ab223013)
      Western blot - Anti-Lamin B Receptor/LBR antibody (ab223013)
      Anti-Lamin B Receptor/LBR antibody (ab223013) at 1/1000 dilution + Jurkat cell lysate

      Predicted band size: 71 kDa

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab223013? Please let us know so that we can cite the reference in this datasheet.

    ab223013 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Immunocytochemistry/ Immunofluorescence abreview for Anti-Lamin B Receptor/LBR antibody

    Poor
    Abreviews
    Abreviews
    abreview image
    Application
    Immunocytochemistry/ Immunofluorescence
    Sample
    Mouse Cell (C127)
    Permeabilization
    Yes - 0.2% Triton
    Specification
    C127
    Blocking step
    Fish Skin Gelatin as blocking agent for 15 minute(s) · Concentration: 0.5% · Temperature: 22°C
    Fixative
    Formaldehyde
    Read More

    Abcam user community

    Verified customer

    Submitted Jan 18 2018

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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