Overview

  • Product name

    Anti-Laminin alpha 4/LAMA4 antibody [3H2]
    See all Laminin alpha 4/LAMA4 primary antibodies
  • Description

    Mouse monoclonal [3H2] to Laminin alpha 4/LAMA4
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-P, WB, IPmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length native protein (purified) corresponding to Human Laminin alpha 4/LAMA4. Immunoaffinity-purified Laminin 411 (laminin-8 (alpha4beta1gamma1) from platelets.
    Database link: Q16363

  • Positive control

    • Human platelet lysate. Human embryonic kidney preparation.

Properties

Applications

Our Abpromise guarantee covers the use of ab205568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 202 kDa.

Reduced conditions.

IP Use a concentration of 0.5 mg/ml.

Target

  • Function

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificity

    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
  • Involvement in disease

    Cardiomyopathy, dilated 1JJ
  • Sequence similarities

    Contains 4 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
  • Domain

    The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain G is globular.
  • Cellular localization

    Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMD1JJ antibody
    • DKFZp686D23145 antibody
    • LAMA3 antibody
    • LAMA3, formerly antibody
    • LAMA4 1 antibody
    • LAMA4 antibody
    • LAMA4*-1 antibody
    • LAMA4_HUMAN antibody
    • Laminin alpha 4 antibody
    • Laminin alpha 4 chain antibody
    • Laminin subunit alpha 4 precursor antibody
    • Laminin subunit alpha-4 antibody
    • Laminin-14 subunit alpha antibody
    • Laminin-8 subunit alpha antibody
    • Laminin-9 subunit alpha antibody
    see all

Images

  • All lanes : Anti-Laminin alpha 4/LAMA4 antibody [3H2] (ab205568) at 1 µg/ml

    Lane 1 : Human platelet lysate; reducing conditions
    Lane 2 : Human platelet lysate; non-reducing conditions

    Predicted band size: 202 kDa

  • Immunohistochemical analysis of Human embryonic kidney preparation labeling Laminin alpha 4/LAMA4 with ab205568 at 10 µg/ml followed by a fluorescent probe.

References

ab205568 has not yet been referenced specifically in any publications.

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