Overview

  • Product name

    Anti-Laminin alpha 4/LAMA4 antibody
    See all Laminin alpha 4/LAMA4 primary antibodies
  • Description

    Rabbit polyclonal to Laminin alpha 4/LAMA4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Laminin alpha 4/LAMA4 aa 1581-1809 (C terminal).
    Database link: Q16363

  • Positive control

    • PC14 xenograft.
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab154314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • Tissue specificity

    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
  • Involvement in disease

    Cardiomyopathy, dilated 1JJ
  • Sequence similarities

    Contains 4 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
  • Domain

    The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domain G is globular.
  • Cellular localization

    Secreted, extracellular space, extracellular matrix, basement membrane. Major component.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMD1JJ antibody
    • DKFZp686D23145 antibody
    • LAMA3 antibody
    • LAMA3, formerly antibody
    • LAMA4 1 antibody
    • LAMA4 antibody
    • LAMA4*-1 antibody
    • LAMA4_HUMAN antibody
    • Laminin alpha 4 antibody
    • Laminin alpha 4 chain antibody
    • Laminin subunit alpha 4 precursor antibody
    • Laminin subunit alpha-4 antibody
    • Laminin-14 subunit alpha antibody
    • Laminin-8 subunit alpha antibody
    • Laminin-9 subunit alpha antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded PC14 xenograft labeling Laminin alpha 4/LAMA4  using ab154314 at 1/100 dilution.

References

ab154314 has not yet been referenced specifically in any publications.

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