Key features and details
- Rabbit polyclonal to Laminin alpha 4/LAMA4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Laminin alpha 4/LAMA4 antibody
See all Laminin alpha 4/LAMA4 primary antibodies
DescriptionRabbit polyclonal to Laminin alpha 4/LAMA4
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- IHC-P: Human smooth muscle tissue.
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab244345 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionBinding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Tissue specificityIn adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis.
Involvement in diseaseCardiomyopathy, dilated 1JJ
Sequence similaritiesContains 4 laminin EGF-like domains.
Contains 5 laminin G-like domains.
DomainThe alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domain G is globular.
Cellular localizationSecreted, extracellular space, extracellular matrix, basement membrane. Major component.
- Information by UniProt
- CMD1JJ antibody
- DKFZp686D23145 antibody
- LAMA3 antibody
Formalin-fixed, paraffin-embedded human smooth muscle tissue and skeletal muscle tissue stained for Laminin alpha 4/LAMA4 with ab244345 at 1/50 dilution in immunohistochemical analysis. RNA-seq data are shown for the same tissues.
Formalin-fixed, paraffin-embedded human smooth muscle tissue stained for Laminin alpha 4/LAMA4 with ab244345 at 1/50 dilution in immunohistochemical analysis.
Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for Laminin alpha 4/LAMA4 with ab244345 at 1/50 dilution in immunohistochemical analysis.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab244345 has not yet been referenced specifically in any publications.