Overview

  • Product name

    Lamotrigine, Anticonvulsant
  • Description

    Anticonvulsant
  • Biological description

    Anticonvulsant. Active in vivo and orally bioavailable. Various pharmacological activities including sodium channel blocking (Ki = 9 μM). Selectively inhibits seizure discharges over normal neuronal activity.
  • Purity

    > 98%
  • CAS Number

    84057-84-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine
  • Molecular weight

    255.01
  • Molecular formula

    C9H7Cl2N5
  • PubChem identifier

    3878
  • Storage instructions

    Store at -20°C. It is important to note that this is air sensitive and impurities can occur as a result of air oxidation. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 25 mM (with warming) and in ethanol to 25 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lukawski K  et al. Effect of hydrochlorothiazide on the anticonvulsant action of antiepileptic drugs against maximal electroshock-induced seizures in mice. Pharmacol Rep 64:315-20 (2012). Read more (PubMed: 22661181) »
  • Kuo CC & Lu L Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones. Br J Pharmacol 121:1231-8 (1997). Read more (PubMed: 9249262) »
  • Getova DP & Mihaylova AS A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) 53:57-62 (0). Read more (PubMed: 21797108) »

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