Anti-LAMP2 antibody [GL2A7] (ab13524)

Rat monoclonal LAMP2 antibody [GL2A7]. Validated in WB, IP, IHC, ICC, Flow Cyt, ICC/IF and tested in Mouse, Rabbit. Cited in 72 publication(s). Independently reviewed in 12 review(s).

Publishing research using ab13524? Please let us know so that we can cite the reference in this datasheet.

ab13524 has been referenced in 73 publications.

  • You JS  et al. The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy. FASEB J 33:4021-4034 (2019). PubMed: 30509128
  • Mai J  et al. The atheroprotective role of lipoxin A4 prevents oxLDL-induced apoptotic signaling in macrophages via JNK pathway. Atherosclerosis 278:259-268 (2018). PubMed: 30340110
  • Carter HN  et al. Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J Physiol 596:3567-3584 (2018). PubMed: 29781176
  • Tordo J  et al. A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency. Brain 141:2014-2031 (2018). PubMed: 29788236
  • Gleitz HF  et al. Brain-targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms. EMBO Mol Med 10:N/A (2018). PubMed: 29884617
  • Ebner P  et al. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun 9:599 (2018). PubMed: 29426817
  • Lloyd-Lewis B  et al. Stat3-mediated alterations in lysosomal membrane protein composition. J Biol Chem 293:4244-4261 (2018). PubMed: 29343516
  • Chen J  et al. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature N/A:N/A (2018). PubMed: 29769719
  • Gradzka S  et al. Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes. Cell Death Dis 9:529 (2018). PubMed: 29743550
  • Hua R  et al. cPKC?-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion. Int J Mol Sci 19:N/A (2018). PubMed: 29734780
  • Brownstein AJ  et al. Heat stress causes dysfunctional autophagy in oxidative skeletal muscle. Physiol Rep 5:N/A (2017). WB . PubMed: 28646096
  • Hammerling BC  et al. A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance. Nat Commun 8:14050 (2017). PubMed: 28134239
  • Perland E  et al. The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake. J Mol Neurosci 61:199-214 (2017). PubMed: 27981419
  • Mizunoe Y  et al. Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice. Autophagy 13:642-653 (2017). PubMed: 28121218
  • Tan HWS  et al. Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation. Nat Commun 8:338 (2017). PubMed: 28835610
  • Zhang CS  et al. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature 548:112-116 (2017). PubMed: 28723898
  • Shingu T  et al. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet 49:75-86 (2017). PubMed: 27841882
  • Blank T  et al. Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa. Front Immunol 8:1930 (2017). PubMed: 29354133
  • Sergin I  et al. Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat Commun 8:15750 (2017). PubMed: 28589926
  • Boal F  et al. PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment. Cell Rep 14:750-759 (2016). PubMed: 26776508
  • Magliarelli HF  et al. Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3. Cell Death Dis 7:e2411 (2016). IF . PubMed: 27735945
  • Li S  et al. Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36. Open Biol 6:N/A (2016). IHC-P ; Mouse . PubMed: 27512143
  • Motas S  et al. CNS-directed gene therapy for the treatment of neurologic and somatic mucopolysaccharidosis type II (Hunter syndrome). JCI Insight 1:e86696 (2016). PubMed: 27699273
  • Marcó S  et al. Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC. Dis Model Mech 9:999-1013 (2016). IHC-P ; Mouse . PubMed: 27491071
  • Sellner S  et al. Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1. Acta Neuropathol Commun 4:102 (2016). IHC ; Mouse . PubMed: 27639555
  • Tjondrokoesoemo A  et al. Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice. J Biol Chem 291:9920-8 (2016). PubMed: 26966179
  • Weis VG  et al. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol 2:131-157 (2016). PubMed: 27019864
  • Shang Y  et al. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy 12:1575-92 (2016). PubMed: 27310465
  • Sorrell SL  et al. Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis. Kidney Int 89:105-112 (2016). PubMed: 26398495
  • Marzesco AM  et al. Highly potent intracellular membrane-associated Aß seeds. Sci Rep 6:28125 (2016). WB . PubMed: 27311744
  • Tian T  et al. Acupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain. Sci Rep 6:19714 (2016). PubMed: 26792101
  • Yadav RK  et al. TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy and reduces renal dysfunction in a cyclosporine A-induced nephrotoxicity model. Autophagy 11:1760-74 (2015). PubMed: 26305401
  • Goldmann T  et al. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. EMBO J 34:1612-29 (2015). PubMed: 25896511
  • Wang C  et al. A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles. Nat Commun 6:8524 (2015). PubMed: 26437053
  • Chen S  et al. Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis. Autophagy 11:2346-57 (2015). PubMed: 26553601
  • Li C & Siragy HM (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab 309:E302-10 (2015). WB ; Mouse . PubMed: 26081285
  • Kubli DA  et al. PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLoS One 10:e0130707 (2015). FM ; Mouse . PubMed: 26110811
  • Nemazanyy I  et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun 6:8283 (2015). PubMed: 26387534
  • Katayama A  et al. Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis. Sci Rep 5:16920 (2015). IHC-Fr ; Mouse . PubMed: 26581806
  • Wu F  et al. Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease. Neuroscience 284:900-11 (2015). PubMed: 25446361
  • Ye J  et al. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev 29:2331-6 (2015). PubMed: 26543160
  • Sharifi MN  et al. Measuring autophagy in stressed cells. Methods Mol Biol 1292:129-50 (2015). PubMed: 25804753
  • Saleem A  et al. p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol 306:C241-9 (2014). WB . PubMed: 24284795
  • Yang S  et al. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol 3:63-71 (2014). WB ; Rat . PubMed: 25462067
  • Brot S  et al. Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites. J Biol Chem 289:2261-76 (2014). Mouse . PubMed: 24324268
  • Xiu Y  et al. Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. J Clin Invest 124:297-310 (2014). ICC . PubMed: 24316970
  • Yang S  et al. Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model. Cell Death Dis 5:e1217 (2014). WB ; Rat . PubMed: 24810053
  • Pensa S  et al. The PI3K regulatory subunits p55a and p50a regulate cell death in vivo. Cell Death Differ N/A:N/A (2014). PubMed: 24902901
  • Honda S  et al. Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nat Commun 5:4004 (2014). PubMed: 24895007
  • Tyzack GE  et al. Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun 5:4294 (2014). ICC/IF ; Mouse . PubMed: 25014177
  • Nickerson KP  et al. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One 9:e101789 (2014). ICC/IF ; Mouse . PubMed: 25000398
  • Lenhart KC  et al. GRAF1 promotes ferlin-dependent myoblast fusion. Dev Biol 393:298-311 (2014). PubMed: 25019370
  • Falk DJ  et al. Peripheral nerve and neuromuscular junction pathology in Pompe disease. Hum Mol Genet N/A:N/A (2014). Mouse . PubMed: 25217571
  • Sargeant TJ  et al. Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Nat Cell Biol 16:1057-68 (2014). PubMed: 25283994
  • Liang N  et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med 211:2249-63 (2014). ICC/IF ; Mouse . PubMed: 25288394
  • Choi S  et al. Globotriaosylceramide induces lysosomal degradation of endothelial KCa3.1 in fabry disease. Arterioscler Thromb Vasc Biol 34:81-9 (2014). PubMed: 24158513
  • Posey AD  et al. EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development. Dev Biol 387:179-90 (2014). PubMed: 24440153
  • Coulson-Thomas VJ  et al. Transplantation of human umbilical mesenchymal stem cells cures the corneal defects of mucopolysaccharidosis VII mice. Stem Cells 31:2116-26 (2013). PubMed: 23897660
  • Kierdorf K  et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci 16:273-80 (2013). Mouse . PubMed: 23334579
  • Jacobs BL  et al. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. J Physiol 591:4611-20 (2013). PubMed: 23732640
  • Goldmann T  et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci 16:1618-26 (2013). PubMed: 24077561
  • Li S  et al. Cathepsin B Contributes to Autophagy-related 7 (Atg7)-induced Nod-like Receptor 3 (NLRP3)-dependent Proinflammatory Response and Aggravates Lipotoxicity in Rat Insulinoma Cell Line. J Biol Chem 288:30094-104 (2013). WB ; Rat . PubMed: 23986436
  • Arnandis T  et al. Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization. Cell Death Differ : (2012). PubMed: 22555453
  • Ogmundsdóttir MH  et al. Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes. PLoS One 7:e36616 (2012). PubMed: 22574197
  • Moles A  et al. Cathepsin B overexpression due to Acid sphingomyelinase ablation promotes liver fibrosis in niemann-pick disease. J Biol Chem 287:1178-88 (2012). WB, ICC/IF . PubMed: 22102288
  • Demonbreun AR  et al. Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy. Hum Mol Genet 20:779-89 (2011). ICC/IF ; Mouse . PubMed: 21127009
  • Kreuzaler PA  et al. Stat3 controls lysosomal-mediated cell death in vivo. Nat Cell Biol 13:303-9 (2011). WB ; Mouse . PubMed: 21336304
  • Li X  et al. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci 51:5019-29 (2010). ICC/IF ; Mouse . PubMed: 20463324
  • Demonbreun AR  et al. Myoferlin is required for insulin-like growth factor response and muscle growth. FASEB J 24:1284-95 (2010). WB, ICC/IF ; Mouse . PubMed: 20008164
  • Wu K  et al. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res 89:319-32 (2009). IHC-Fr ; Mouse . PubMed: 19345210
  • Takahashi K  et al. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 4:e124 (2007). PubMed: 17425404
  • Dharmawardhane S  et al. Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J Cell Biol 138:1265-78 (1997). PubMed: 9298982
  • Granger BL  et al. Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells. J Biol Chem 265:12036-43 (1990). PubMed: 2142158

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