Overview

  • Product name

  • Description

    Rabbit polyclonal to LAMTOR1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment, corresponding to amino acids 9-156 of Human LAMTOR1.

  • Positive control

    • Human rectum tissue; A549 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab121157 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.

Target

  • Function

    Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
  • Sequence similarities

    Belongs to the LAMTOR1 family.
  • Cellular localization

    Late endosome membrane. Lysosome membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • C11orf59 antibody
    • LAMTOR1 antibody
    • Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 antibody
    • Lipid raft adaptor protein p18 antibody
    • LTOR1_HUMAN antibody
    • p18 antibody
    • p27Kip1-releasing factor from RhoA antibody
    • p27RF-Rho antibody
    • PDRO antibody
    • PP7157 antibody
    • Protein associated with DRMs and endosomes antibody
    • Ragulator complex protein LAMTOR1 antibody
    • ragulator complex protein PDRO antibody
    • Ragulator1 antibody
    • RhoA activator C11orf59 antibody
    see all

Images

  • ab121157 at 1/350 dilution staining LAMTOR1 in Paraffin-emebedded Human Rectum tissue by Immunohistochemistry.

    Note:strong cytoplasmic positivity, with a granular pattern, in glandular cells.
  • All lanes : Anti-LAMTOR1 antibody (ab121157) at 0.4 µg/ml

    Lane 1 : MCF-7 cells transfected with control siRNA
    Lanes 2-3 : MCF-7 cells transfected with target specific siRNA probe
  • Anti-LAMTOR1 antibody (ab121157) at 0.4 µg/ml + A549 cell lysate

References

ab121157 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab121157.
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